Evidence map›Paper›PMID 32051268›Full record

ArticleJournal of virology2020

Reverse Genetics Reveals a Role of Rotavirus VP3 Phosphodiesterase Activity in Inhibiting RNase L Signaling and Contributing to Intestinal Viral Replication

Yanhua Song, Ningguo Feng, Liliana Sanchez-Tacuba, Linda L Yasukawa, Lili Ren, Robert H Silverman, Siyuan Ding, Harry B Greenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Recurrent viral capture of cellular phosphodiesterases that antagonize OAS-RNase L.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 2 countries.

Yanhua Song *Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.
Ningguo Feng *Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.
Liliana Sanchez-TacubaDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.
Linda L YasukawaDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA.
Lili RenSchool of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Robert H SilvermanDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Siyuan DingDepartment of Molecular Microbiology, Washington University in St. Louis, St. Louis, Missouri, USA siyuan.ding@wustl.edu hbgreen@stanford.edu.
Harry B GreenbergDepartment of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, California, USA siyuan.ding@wustl.edu hbgreen@stanford.edu.
Palo Alto Veterans Institute for Research · USCleveland Clinic Lerner College of Medicine · USNanjing Tech University · CNStanford University · USVA Palo Alto Health Care System · USWashington University in St. Louis · US

Funding

Stanford/UNC Biomimetic U19 Research CenterU19AI116484 · NIAID · STANFORD UNIVERSITY · PI GREENBERG, HARRY BERNARD · 2015 to 2025
$13.5M
Control of Viral Pathogenesis by Regulation of 2-5A LevelsR01AI104887 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SILVERMAN, ROBERT H., WEISS, SUSAN R · 2013 to 2023
$7.6M
Regulation of Rotavirus Replication, Virulence, and Host Range Restriction by the Innate Immune SystemR01AI125249 · NIAID · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI GREENBERG, HARRY BERNARD · 2017 to 2021
$2.1M
Interferon-Stimulated Gene Inhibition of Rotavirus Replication and Viral AntagonismR01AI150796 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2024
$2.0M
ANTIVIRAL MECHANISMS OF 2-5A-DEPENDENT RNASE LR01AI135922 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI SILVERMAN, ROBERT H. · 2017 to 2021
$2.0M
Genetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionR00AI135031 · NIAID · WASHINGTON UNIVERSITY · PI DING, SIYUAN · 2020 to 2021
$498k
Genetic and Biochemical Interrogation of Rotavirus-Cohesin InteractionK99AI135031 · NIAID · STANFORD UNIVERSITY · PI DING, SIYUAN · 2018 to 2018
$132k
BLRD VA I01 BX000158NIAID NIH HHS K99 AI135031NIAID NIH HHS R00 AI135031NIAID NIH HHS R01 AI104887NIAID NIH HHS R01 AI125249NIAID NIH HHS R01 AI135922NIAID NIH HHS R01 AI150796NIAID NIH HHS U19 AI116484
6 · The paper itself

Abstract

Our understanding of how rotavirus (RV) subverts host innate immune signaling has greatly increased over the past decade. However, the relative contribution of each virus-encoded innate immune antagonist has not been fully studied in the context of RV infection

Indexed as

Adenine NucleotidesAnimalsCapsid ProteinsCell LineChlorocebus aethiopsEndoribonucleasesFemaleHost-Pathogen InteractionsImmunity, InnateInterferonsMaleMiceMice, Inbred C57BLOligoribonucleotidesPhosphoric Diester HydrolasesPolynucleotide Ligases2-5A-dependent ribonuclease2',5'-oligoadenylate(2'-5')oligo-isoadenylate synthetaseAdenine NucleotidesCapsid ProteinsEndoribonucleasesInterferonsOligoribonucleotidesPhosphoric Diester HydrolasesPolynucleotide LigasesRotavirus VaccinesViral Nonstructural ProteinsVP3 protein, Rotavirusgastrointestinal infectioninnate immunityinterferonsrotavirusvirus-host interactions

Identifiers

PMID32051268
PMCPMC7163120
OpenAlexW3005831876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.