Evidence map›Paper›PMID 32051263›Full record

ArticleJournal of clinical microbiology2020

Development of a Novel and Rapid Antibody-Based Diagnostic for Chronic Staphylococcus aureus Infections Based on Biofilm Antigens.

Janette M Harro, Mark E Shirtliff, William Arnold, Jennifer M Kofonow, Chad Dammling, Yvonne Achermann, Kristen Brao, Javad Parvizi, Jeff G Leid

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Editorial: ESKAPE biofilm: challenges and solutions.Frontiers in cellular and infection microbiology · 2023
    Article
  3. Speciality Grand Challenge for "Biofilms".Frontiers in cellular and infection microbiology · 2021
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Janette M HarroDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA jharro@umaryland.edu.
Mark E ShirtliffDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA.
William ArnoldThe Rothman Institute, Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Jennifer M KofonowNorthern Arizona University, Flagstaff, Arizona, USA.
Chad DammlingDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Yvonne AchermannDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Kristen BraoDepartment of Microbial Pathogenesis, School of Dentistry, University of Maryland-Baltimore, Baltimore, Maryland, USA.
Javad ParviziThe Rothman Institute, Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA.
Jeff G LeidNorthern Arizona University, Flagstaff, Arizona, USA.
University of Maryland, Baltimore · USNorthern Arizona University · USRothman Institute · USThomas Jefferson University Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prosthetic joint infections are difficult to diagnose and treat due to biofilm formation by the causative pathogens. Pathogen identification relies on microbial culture that requires days to weeks, and in the case of chronic biofilm infections, lacks sensitivity. Diagnosis of infection is often delayed past the point of effective treatment such that only the removal of the implant is curative. Early diagnosis of an infection based on antibody detection might lead to less invasive, early interventions. Our study examined antibody-based assays against the

Indexed as

OsteomyelitisStaphylococcal InfectionsAnimalsAntigens, BacterialBiofilmsRabbitsStaphylococcus aureusAntigens, Bacterialbiofilmdiagnosticinfectionprosthetic joint infectionStaphylococcus aureus

Identifiers

PMID32051263
PMCPMC7180261
OpenAlexW3006124415

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.