ArticleScience translational medicine2020
Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses.
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Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 219 papers, 1 of them a synthesis that pooled it.
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219citing papers in PubMed, 1 pooled it
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Who cites it
219 citing papers in PubMed, 1 synthesis or guideline pooled it, 408 citations in OpenAlex.
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159 more citing papers are in PubMed but not listed here.
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Authors and funding
43 authors at 11 institutions in 2 countries.
Jesse M JaynesCollege of Agriculture, Environment and Nutrition Sciences, Integrative Biosciences Program, Tuskegee University, Tuskegee, AL 36088, USA.ORCID 0000-0001-7795-8952
Rushikesh SableRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0003-2137-9040
Michael RonzettiNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0001-5034-7692
Wendy BautistaCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.ORCID 0000-0003-2816-4931
Zachary KnottsRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0001-7557-1922
Abisola Abisoye-OgunniyanDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.ORCID 0000-0002-8646-9031
Dandan LiRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Raul CalvoNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Myagmarjav DashnyamNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0003-2307-3002
Anju SinghNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Theresa GuerinCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.ORCID 0000-0003-4046-243X
Jason WhiteDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
Sarangan RavichandranAdvanced Biomedical Computing Center, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.ORCID 0000-0001-6349-0172
Parimal KumarSequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.ORCID 0000-0003-1982-7983
Keyur TalsaniaCCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.
Vicky ChenCCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.ORCID 0000-0003-4595-154X
Anghesom GhebremedhinDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
Balasubramanyam KaranamDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.ORCID 0000-0002-0782-2539
Ahmad Bin SalamDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.ORCID 0000-0002-9315-3211
Ruksana AminDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA.
Taivan OdzorigRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-0877-2692
Taylor AikenThoracic and GI Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.ORCID 0000-0003-1139-9822
Victoria NguyenRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Yansong BianRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
Jelani C ZarifDepartment of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Amber E de GrootJames Buchanan Brady Urological Institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Monika MehtaSequencing Facility and Single Cell Analysis Facility, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.
Lixin FanBasic Science Program, Frederick National Laboratory for Cancer Research, SAXS Core Facility, Center for Cancer Research of the National Cancer Institute, Frederick, MD 21701, USA.
Xin HuNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Anton SimeonovNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Nathan PateCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.ORCID 0000-0003-0409-4190
Mones Abu-AsabSection of Histopathology, National Eye Institute, Bethesda, MD 20892, USA.ORCID 0000-0002-4047-1232
Marc FerrerNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
Noel SouthallNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.ORCID 0000-0003-4500-880X
Chan-Young OckDepartment of Hemato Oncology, Seoul National University Hospital, Seoul 03080, Korea.
Yongmei ZhaoCCR-SF Bioinformatics Group, Advanced Biomedical and Computational Sciences, Biomedical Informatics and Data Science, Advanced Technology Research Facility, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD 21701, USA.ORCID 0000-0003-0800-4658
Henry LopezMuriGenics Inc., Vallejo, CA 94592, USA.ORCID 0000-0002-4795-4763
Serguei KozlovCenter for Advanced Preclinical Research, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21702, USA.ORCID 0000-0001-5253-2867
Natalia de ValCancer Research Technology Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc., Frederick, MD 21701, USA.ORCID 0000-0002-1506-2023
Clayton C YatesDepartment of Biology and Center for Cancer Research, Tuskegee University, Tuskegee, AL 36088, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov.ORCID 0000-0001-5420-9852
Bolormaa BaljinnyamNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov.ORCID 0000-0001-9548-4965
Juan MaruganNational Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov.ORCID 0000-0002-3951-7061
Udo RudloffRare Tumor Initiative, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA. cyates@tuskegee.edu baljinnb@mail.nih.gov maruganj@mail.nih.gov rudloffu@mail.nih.gov.ORCID 0000-0003-2137-9040
Leidos (United States) · USNational Institutes of Health · USNational Cancer Institute · USCenter for Cancer Research · USAgenus (United States) · USBloomberg (United States) · USFrederick National Laboratory for Cancer Research · USJohns Hopkins University · USNational Eye Institute · USSeoul National University Hospital · KRUniversity of Wisconsin–Madison · US
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MCCR Sequencing FacilityZICBC011331 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MALIK, MARIAM · 2010 to 2025
$68.2MTuskegee University Center for Biomedical Research/ Research Centers at Minority InstitutionsU54MD007585 · NIMHD · TUSKEGEE UNIVERSITY · PI Jason Anthony White · 2017 to 2026
$29.4MPreclinical drug development in pancreatic cancerZIABC011267 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI RUDLOFF, UDO · 2010 to 2025
$23.9MResearch Education CoreU54CA118623 · NCI · TUSKEGEE UNIVERSITY · PI STEPHEN O SODEKE · 2005 to 2026
$20.2MTarget validation of CD206 activatorsZIATR000302 · NCATS · NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES · PI MARUGAN, JUAN · 2017 to 2025
$1.9MIntramural NIH HHS ZIA BC011267Intramural NIH HHS ZIA TR000302NCI NIH HHS P30 CA006973NCI NIH HHS U54 CA118623NIMHD NIH HHS U54 MD007585
Abstract
Solid tumors elicit a detectable immune response including the infiltration of tumor-associated macrophages (TAMs). Unfortunately, this immune response is co-opted into contributing toward tumor growth instead of preventing its progression. We seek to reestablish an antitumor immune response by selectively targeting surface receptors and endogenous signaling processes of the macrophage subtypes driving cancer progression. RP-182 is a synthetic 10-mer amphipathic analog of host defense peptides that selectively induces a conformational switch of the mannose receptor CD206 expressed on TAMs displaying an M2-like phenotype. RP-182-mediated activation of this receptor in human and murine M2-like macrophages elicits a program of endocytosis, phagosome-lysosome formation, and autophagy and reprograms M2-like TAMs to an antitumor M1-like phenotype. In syngeneic and autochthonous murine cancer models, RP-182 suppressed tumor growth, extended survival, and was an effective combination partner with chemo- or immune checkpoint therapy. Antitumor activity of RP-182 was also observed in CD206
Indexed as
Mannose-Binding LectinsTumor-Associated MacrophagesAnimalsCell Line, TumorHumansImmunity, InnateLectins, C-TypeMannose ReceptorMiceReceptors, Cell SurfaceLectins, C-TypeMannose-Binding LectinsMannose ReceptorReceptors, Cell Surface
Identifiers
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