Evidence map›Paper›PMID 32051193›Full record

ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2020

Mendelian Randomization of Circulating Polyunsaturated Fatty Acids and Colorectal Cancer Risk.

Nikhil K Khankari, Barbara L Banbury, Maria C Borges, Philip Haycock, Demetrius Albanes, Volker Arndt, Sonja I Berndt, Stéphane Bézieau, Hermann Brenner, Peter T Campbell and 46 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02328677 (ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02328677 recruitingnot on this map

ColoCare Transdisciplinary Research in Colorectal Cancer Prognosis

TypeobservationalSponsorUniversity of UtahRan2007 to 2030Enrolled5,000ConditionsColorectal Cancer
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  17. Mendelian Randomization Analysis of n-6 Polyunsaturated Fatty Acid Levels and Pancreatic Cancer Risk.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

56 authors at 20 institutions in 9 countries.

Nikhil K KhankariDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee. nikhil.khankari@vumc.org.
Barbara L BanburyPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-7332-7117
Maria C BorgesMedical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-7785-4547
Philip HaycockMedical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom.ORCID 0000-0001-5001-3350
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Volker ArndtDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-9320-8684
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Stéphane BézieauService de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0001-7494-9655
Peter T CampbellBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, Georgia.
Graham CaseyCenter for Public Health Genomics, University of Virginia, Charlottesville, Virginia.
Andrew T ChanDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Jenny Chang-ClaudeUniversity Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.ORCID 0000-0001-8919-1971
David V ContiDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Michelle CotterchioPrevention and Cancer Control, Cancer Care Ontario, Toronto, Ontario, Canada.
Dallas R EnglishCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0001-7828-8188
Jane C FigueiredoDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Graham G GilesCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0003-4946-9099
Edward L GiovannucciChanning Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Marc J GunterNutrition and Metabolism Section, International Agency for Research on Cancer, World Health Organization, Lyon, France.
Jochen HampeDepartment of Medicine, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany.
Michael HoffmeisterDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID 0000-0002-8307-3197
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Mark A JenkinsCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Amit D JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Mathieu LemirePanCuRx Translational Research Initiative, Ontario, Institute for Cancer Research, Toronto, Ontario, Canada.
Christopher I LiPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Li LiDepartment of Family Medicine, University of Virginia, Charlottesville, Virginia.
Annika LindblomDepartment of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden.
Vicente MartínÁrea de Medicina Preventiva y Salud Publica, Universidad de León, León, Spain.ORCID 0000-0003-0552-2804
Victor MorenoCancer Prevention and Control Program, Catalan Institute of Oncology-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.ORCID 0000-0002-2818-5487
Polly A NewcombPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Kenneth OffitClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-8494-732X
Gad RennertDepartment of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel.ORCID 0000-0002-8512-068X
Lori C SakodaPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0002-0900-5735
Clemens SchafmayerDepartment of General and Thoracic Surgery, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Stephanie L SchmitDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Martha L SlatteryDivision of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-1655-6543
Mingyang SongDivision of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Stephen N ThibodeauDivision of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
Cornelia M UlrichHuntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
Stephanie J WeinsteinDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.ORCID 0000-0002-3834-1535
Emily WhitePublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Aung Ko WinCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.ORCID 0000-0002-2794-5261
Alicja WolkInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Michael O WoodsDiscipline of Genetics, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Qiuyin CaiDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Joshua C DennyVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0002-3049-7332
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Harvey J MurffDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Stephen B GruberDepartment of Medical Oncology, City of Hope National Medical Center, Duarte, California.
Ulrike PetersPublic Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University Medical Center · USThe University of Melbourne · AUUniversity of Southern California · USCenter for Cancer Research · USGerman Cancer Research Center · DEUniversity of Washington · USBristol City Council · GBFred Hutch Cancer Center · USHarvard University · USUniversity of Virginia · USAmerican Cancer Society · USBrigham and Women's Hospital · USBroad Institute · USCancer Care Ontario · CACancer Center of Hawaii · USCentre Hospitalier Universitaire de Nantes · FRCentre international de recherche sur le cancer · FRCity Of Hope National Medical Center · USHuntsman Cancer Institute · USInstitut Català d'Oncologia · ES

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian Esvelt · 1985 to 2026
$296.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Understanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4M
Tissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI EL-BARDEESY, NABEEL, SELLERS, WILLIAM R · 2007 to 2023
$33.2M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RICHARD M. PEEK · 2002 to 2026
$29.9M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI David V Conti · 2016 to 2026
$25.5M
JH/CIDR Genotyping for Genome-Wide Association StudiesU01HG004438 · NHGRI · JOHNS HOPKINS UNIVERSITY · PI VALLE, DAVID · 2007 to 2011
$24.2M
GENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2M
Cancer Research UK 20138Cancer Research UK C52724/A20138CCR NIH HHS N01 RC037004Intramural NIH HHS Z01 CP010200Medical Research Council MC_UU_00011/6Medical Research Council MR/P014054/1NCI NIH HHS HHSN261201300012INCI NIH HHS K05 CA154337NCI NIH HHS K07 CA190673NCI NIH HHS K99 CA215314NCI NIH HHS K99 CA215360NCI NIH HHS N01 CN045165NCI NIH HHS N01 CN067009NCI NIH HHS N01 PC035137NCI NIH HHS N01 PC035142NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS P01 CA196569NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015704NCI NIH HHS P30 CA076292NCI NIH HHS P50 CA127003NCI NIH HHS R00 CA215314NCI NIH HHS R00 CA215360NCI NIH HHS R01 CA042182NCI NIH HHS R01 CA048998NCI NIH HHS R01 CA059045NCI NIH HHS R01 CA060987NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA076366NCI NIH HHS R01 CA081488NCI NIH HHS R01 CA136726NCI NIH HHS R01 CA137178NCI NIH HHS R01 CA151993NCI NIH HHS R01 CA189184NCI NIH HHS R01 CA197350NCI NIH HHS R01 CA201407NCI NIH HHS R01 CA207371NCI NIH HHS R35 CA197735NCI NIH HHS R37 CA054281NCI NIH HHS U01 CA074783NCI NIH HHS U01 CA074794NCI NIH HHS U01 CA074799NCI NIH HHS U01 CA074800NCI NIH HHS U01 CA074806NCI NIH HHS U01 CA097735NCI NIH HHS U01 CA122839NCI NIH HHS U01 CA137088NCI NIH HHS U01 CA164930NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167551NCI NIH HHS U01 CA167552NCI NIH HHS U01 CA206110NCI NIH HHS U19 CA148107NCI NIH HHS U24 CA074783NCI NIH HHS U24 CA074794NCI NIH HHS U24 CA074799NCI NIH HHS U24 CA074800NCI NIH HHS U24 CA074806NCI NIH HHS U24 CA097735NCI NIH HHS UM1 CA167552NCI NIH HHS UM1 CA186107NHGRI NIH HHS U01 HG004438NHGRI NIH HHS U01 HG004446NIDDK NIH HHS P30 DK058404NIEHS NIH HHS T32 ES013678NIH HHS S10 OD020069World Health Organization 001
6 · The paper itself

Abstract

backgroundResults from epidemiologic studies examining polyunsaturated fatty acids (PUFA) and colorectal cancer risk are inconsistent. Mendelian randomization may strengthen causal inference from observational studies. Given their shared metabolic pathway, examining the combined effects of aspirin/NSAID use with PUFAs could help elucidate an association between PUFAs and colorectal cancer risk.

methodsInformation was leveraged from genome-wide association studies (GWAS) regarding PUFA-associated SNPs to create weighted genetic scores (wGS) representing genetically predicted circulating blood PUFAs for 11,016 non-Hispanic white colorectal cancer cases and 13,732 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO). Associations per SD increase in the wGS were estimated using unconditional logistic regression. Interactions between PUFA wGSs and aspirin/NSAID use on colorectal cancer risk were also examined.

resultsModest colorectal cancer risk reductions were observed per SD increase in circulating linoleic acid [OR

conclusionsOur study suggests that higher circulating shorter-chain PUFAs (i.e., LA and ALA) were associated with reduced colorectal cancer risk, whereas longer-chain PUFAs (i.e., AA, EPA, and DPA) were associated with an increased colorectal cancer risk. IMPACT: The interaction of PUFAs with aspirin/NSAID use indicates a shared colorectal cancer inflammatory pathway. Future research should continue to improve PUFA genetic instruments to elucidate the independent effects of PUFAs on colorectal cancer.

Indexed as

AgedAnti-Inflammatory Agents, Non-SteroidalArachidonic AcidCase-Control StudiesColorectal NeoplasmsCyclooxygenase 2Datasets as TopicEicosapentaenoic AcidFatty Acids, UnsaturatedFemaleGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideAnti-Inflammatory Agents, Non-SteroidalArachidonic AcidCyclooxygenase 2docosapentaenoic acidEicosapentaenoic AcidFatty Acids, UnsaturatedPTGS2 protein, human

Identifiers

PMID32051193
PMCPMC7125012
OpenAlexW3006055254

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.