SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2020
Subglottic secretion drainage for preventing ventilator-associated pneumonia: an overview of systematic reviews and an updated meta-analysis.
Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06113939 (Prevention of Infection of the Respiratory Tract by Applying Methods That Are Non-Invasive for Extraction of Secretions. An Open Label, Randomized, Assessor-blinded Trial.), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prevention of Infection of the Respiratory Tract by Applying Methods That Are Non-Invasive for Extraction of Secretions. An Open Label, Randomized, Assessor-blinded Trial.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of Intermittent and Continuous Subglottic Secretion Drainage in Preventing the Risk of Ventilator-Associated Pneumonia: A Meta-Analysis of Randomized Control Trials.Medicina (Kaunas, Lithuania) · 2023Pooled it
- Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.Intensive care medicine · 2026Trial
- Alkalized lidocaine in a tapered cuff suppresses endotracheal tube-induced hemodynamic changes: a randomized controlled trial.Journal of anesthesia · 2023Trial
- Effect of clove mouthwash on the incidence of ventilator-associated pneumonia in intensive care unit patients: a comparative randomized triple-blind clinical trial.Clinical oral investigations · 2023Trial
- Development and validation of a risk prediction model for postoperative pneumonia in adult patients undergoing Stanford type A acute aortic dissection surgery: a case control study.Journal of cardiothoracic surgery · 2022Trial
- Airway Pressure Release Ventilation with a Time-Controlled Adaptive Ventilation Strategy (APRV-TCAV) Reverses Endotracheal Secretion Movement Compared with Volume-Control Ventilation: A Bench Study.Journal of clinical medicine · 2026Article
- Ventilator-Associated Pneumonia (VAP) Prevention Bundle: A Multicenter Cross-Sectional Saudi Study to Assess Knowledge, Adherence, and Perceived Barriers Among ICU Practitioners in Hail Region.Pathogens (Basel, Switzerland) · 2026Article
- Clinical application of a novel gravity-weighted continuous oral suction dental pad in preventing ventilator-associated pneumonia in intubated patients.Head & face medicine · 2026Article
- Saudi Guideline for Mechanical Ventilation in Adults.Saudi journal of medicine & medical sciences · 2026Article
- A potential bundle for preventing ventilator-associated pneumonia in the emergency department: A narrative review.The Journal of international medical research · 2026Article
- Risk factors analysis and prediction model construction of LRTI in head and neck cancer patients with tracheostomy based on subglottic sputum aspiration volume.Frontiers in oral health · 2026Article
- Rapid Molecular Diagnostics for MDR Nosocomial Infections in ICUs: Integration with Prevention, Stewardship, and Novel Therapies.Diagnostics (Basel, Switzerland) · 2025Review
- Consensus Statements on Airway Clearance Interventions in Intubated Critically Ill Patients-Protocol for a Delphi Study.Life (Basel, Switzerland) · 2025Article
- The Development of a 10-Item Ventilator-Associated Pneumonia Care Bundle in the General Intensive Care Unit of a Tertiary Hospital in Vietnam: Lessons Learned.Healthcare (Basel, Switzerland) · 2025Review
- Impact of proactive risk-prevention nursing interventions on the recovery of ICU patients with ventilator-associated pneumonia.Frontiers in medicine · 2025Article
- Article
- Microbiological Concordance of Subglottic Secretion and Tracheal Aspirate Cultures of Critically Ill Patients with Invasive Airway Devices: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Preventing ventilator-associated pneumonia non-pharmacologically.Intensive care medicine · 2024Article
- Specialized nursing intervention on critically ill patient in the prevention of intubation-associated pneumonia: an integrative literature review.Acute and critical care · 2024Article
- Ventilator-Associated Pneumonia, Ventilator-Associated Events, and Nosocomial Respiratory Viral Infections on the Leeside of the Pandemic.Respiratory care · 2024Review
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although several guidelines recommend subglottic secretion drainage as a strategy for prevention of ventilator-associated pneumonia (VAP), its use is not widespread. With the aim to assess the effectiveness of subglottic secretion drainage for preventing VAP and to improve other outcomes such as mortality, duration of mechanical ventilation and length of stay in the intensive care unit (ICU) or hospital, an electronic search of the Cochrane Library, MEDLINE, Web of Science and Embase was undertaken. Nine systematic reviews with meta-analysis (in the overview of reviews) and 20 randomised controlled trials (in the updated meta-analysis) were included.In the overview of reviews, all systematic reviews with meta-analysis included found a positive effect of subglottic secretion drainage in the reduction of incidence of VAP. In the updated meta-analysis, subglottic secretion drainage significantly reduced VAP incidence (risk ratio (RR) 0.56, 95% CI 0.48-0.63; I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.