Observational studyRespiratory research2020
Resistance of the respiratory system measured with forced oscillation technique (FOT) correlates with bronchial thermoplasty response.
Observational study in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02225392 (Unravelling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma), which is not on this map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Unravelling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma
Who cites it
4 citing papers in PubMed, 12 citations in OpenAlex.
- Oscillometry changes reflect clinically meaningful improvement after bronchial thermoplasty for uncontrolled asthma: A case report.Respirology case reports · 2024Article
- Plethysmography-derived gas trapping lacks utility in predicting response to bronchial thermoplasty.ERJ open research · 2022Article
- Non-interventional monitoring of expiratory flow limitation during experimental mechanical ventilation.ERJ open research · 2021Article
- [Application of a multiple linear regression model of FEV1 in pulmonary function test].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundBronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma using radiofrequency energy to target airway remodeling including smooth muscle. The correlation of pulmonary function tests and BT response are largely unknown. Forced Oscillation Technique (FOT) is an effort-independent technique to assess respiratory resistance (Rrs) by using pressure oscillations including small airways.
aimTo investigate the effect of BT on pulmonary function, assessed by spirometry, bodyplethysmography and FOT and explore associations between pulmonary function parameters and BT treatment response.
methodsSevere asthma patients recruited to the TASMA trial were analyzed in this observational cohort study. Spirometry, bodyplethysmography and FOT measurements were performed before and 6 months after BT. Asthma questionnaires (AQLQ/ACQ-6) were used to assess treatment response.
resultsTwenty-four patients were analyzed. AQLQ and ACQ improved significantly 6 months after BT (AQLQ 4.15 (±0.96) to 4.90 (±1.14) and ACQ 2.64 (±0.60) to 2.11 (±1.04), p = 0.004 and p = 0.02 respectively). Pulmonary function parameters remained stable. Improvement in FEV
conclusionPulmonary function remained stable after BT. Improvement in FEV
trial registrationClinicalTrials.gov Identifier: NCT02225392; Registered 26 August 2014.
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