ArticleBMC genomics2020
Transcriptome analysis of fungicide-responsive gene expression profiles in two Penicillium italicum strains with different response to the sterol demethylation inhibitor (DMI) fungicide prochloraz.
Article in BMC genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Recent Advances in Pathogenicity and Biocontrol of PostharvestJournal of fungi (Basel, Switzerland) · 2026Review
- Functional analysis of target of rapamycin in regulating mycelial growth and development in Penicillium italicum.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Insights into the Adaptation ofJournal of fungi (Basel, Switzerland) · 2026Article
- Transcriptomic Profiling of mRNA and lncRNA During the Developmental Transition from Spores to Mycelia inMicroorganisms · 2025Article
- Context-Dependent Fitness Trade-Offs inMicroorganisms · 2025Article
- Comparison and Analysis of Resistance Differences inJournal of fungi (Basel, Switzerland) · 2025Article
- Transcriptome Analysis Reveals Potential Regulators of DMI Fungicide Resistance in the Citrus Postharvest PathogenJournal of fungi (Basel, Switzerland) · 2024Article
- Transcriptome Analysis ofMicroorganisms · 2024Article
- Prochloraz induced alterations in the expression of mRNA in the reproductive system of male offspring mice.PeerJ · 2024Article
- Potential of Alpha-(α)-Solanine as a Natural Inhibitor of Fungus Causing Leaf Spot Disease in Strawberry.Life (Basel, Switzerland) · 2023Article
- Status of Fungicide Resistance and Physiological Characterization of Tebuconazole Resistance inCurrent issues in molecular biology · 2022Article
- Characterization and Functional Analysis of a New Calcium/Calmodulin-Dependent Protein Kinase (CaMK1) in the Citrus Pathogenic FungusJournal of fungi (Basel, Switzerland) · 2022Article
- Transcriptomic Analysis of Resistant and Wild-Type Isolates Revealed Fludioxonil as a Candidate for Controlling the Emerging Isoprothiolane Resistant Populations ofFrontiers in microbiology · 2022Article
- Assessment of Commercial Fungicides against Onion (Journal of fungi (Basel, Switzerland) · 2021Article
- Genome-Wide Analysis of Major Facilitator Superfamily and Its Expression in Response of Poplar toFrontiers in genetics · 2021Article
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPenicillium italicum (blue mold) is one of citrus pathogens causing undesirable citrus fruit decay even at strictly-controlled low temperatures (< 10 °C) during shipping and storage. P. italicum isolates with considerably high resistance to sterol demethylation inhibitor (DMI) fungicides have emerged; however, mechanism(s) underlying such DMI-resistance remains unclear. In contrast to available elucidation on anti-DMI mechanism for P. digitatum (green mold), how P. italicum DMI-resistance develops has not yet been clarified.
resultsThe present study prepared RNA-sequencing (RNA-seq) libraries for two P. italicum strains (highly resistant (Pi-R) versus highly sensitive (Pi-S) to DMI fungicides), with and without prochloraz treatment, to identify prochloraz-responsive genes facilitating DMI-resistance. After 6 h prochloraz-treatment, comparative transcriptome profiling showed more differentially expressed genes (DEGs) in Pi-R than Pi-S. Functional enrichments identified 15 DEGs in the prochloraz-induced Pi-R transcriptome, simultaneously up-regulated in P. italicum resistance. These included ATP-binding cassette (ABC) transporter-encoding genes, major facilitator superfamily (MFS) transporter-encoding genes, ergosterol (ERG) anabolism component genes ERG2, ERG6 and EGR11 (CYP51A), mitogen-activated protein kinase (MAPK) signaling-inducer genes Mkk1 and Hog1, and Ca
conclusionsThe present findings provided transcriptomic evidence on P. italicum DMI-resistance mechanisms and revealed some diversity in anti-DMI strategies between P. italicum and P. digitatum species, contributing to our knowledge on P. italicum DMI-resistance mechanisms.
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