ArticleGenetics, selection, evolution : GSE2020
Beyond large-effect loci: large-scale GWAS reveals a mixed large-effect and polygenic architecture for age at maturity of Atlantic salmon.
Article in Genetics, selection, evolution : GSE, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Genome-wide association analysis using multiple Atlantic salmon populations.Genetics, selection, evolution : GSE · 2025Pooled it
- Temporal Comparison Reveals Weakened Genotype-Phenotype Association at a Major-Effect Locus in Dworshak National Fish Hatchery Steelhead.Evolutionary applications · 2026Article
- A large-effect locus underlies migration timing in North American Atlantic salmon (Salmo salar).Scientific reports · 2026Article
- Early life exploration behaviour and life-history loci are colocalized in an adaptive genomic hotspot in Atlantic salmon.The Journal of animal ecology · 2026Article
- Genotype-Dependent Transcriptome Divergence Associated With Variation at vgll3 in Juvenile Gilthead Seabream (Sparus aurata).Molecular ecology · 2026Article
- Fine mapping and functional annotation of a QTL for resistance to tilapia lake virus in Nile tilapia (Oreochromis niloticus).G3 (Bethesda, Md.) · 2026Article
- GWAS on early sexual maturation across freshwater and seawater environments in domesticated Lochy strain of Atlantic salmon.Genetics, selection, evolution : GSE · 2026Article
- Density-Dependent Expression of Epitranscriptomic, Stress and Appetite Regulating Genes in Atlantic Salmon.Molecular ecology · 2026Article
- The genetic architecture and spatiotemporal dynamics of adaptation across human-modified landscapes.The New phytologist · 2026Review
- Testicular heterochrony in vgll3-mediated maturation age in Atlantic salmon.G3 (Bethesda, Md.) · 2025Article
- Genomic Basis and Climate Change Vulnerability of Migration Timing in Atlantic Salmon (Evolutionary applications · 2025Article
- Genetic Recovery of Two Wild Seatrout Populations Following Long-Term Stocking With Non-Native Conspecifics.Molecular ecology · 2025Article
- Predicting Forest Tree Leaf Phenology Under Climate Change Using Satellite Monitoring and Population-Based Genomic Trait Association.Global change biology · 2025Article
- Heritability and genomic basis of age-at-maturity in Chinook Salmon.The Journal of heredity · 2025Article
- A Framework Integrating GWAS and Genomic Selection to Enhance Prediction Accuracy of Economical Traits in Common Carp.International journal of molecular sciences · 2025Article
- Large effect life-history genomic regions are associated with functional morphological traits in Atlantic salmon.G3 (Bethesda, Md.) · 2025Article
- Genomic Insights Into Inbreeding and Adaptive Divergence of Trout Populations to Inform Genetic Rescue.Evolutionary applications · 2025Article
- Whole-Genome Resequencing Reveals Polygenic Signatures of Directional and Balancing Selection on Alternative Migratory Life Histories.Molecular ecology · 2024Article
- Genomic Signatures of Domestication in European Seabass (Ecology and evolution · 2024Article
- A complex mechanism translating variation of a simple genetic architecture into alternative life histories.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundUnderstanding genetic architecture is essential for determining how traits will change in response to evolutionary processes such as selection, genetic drift and/or gene flow. In Atlantic salmon, age at maturity is an important life history trait that affects factors such as survival, reproductive success, and growth. Furthermore, age at maturity can seriously impact aquaculture production. Therefore, characterizing the genetic architecture that underlies variation in age at maturity is of key interest.
resultsHere, we refine our understanding of the genetic architecture for age at maturity of male Atlantic salmon using a genome-wide association study of 11,166 males from a single aquaculture strain, using imputed genotypes at 512,397 single nucleotide polymorphisms (SNPs). All individuals were genotyped with a 50K SNP array and imputed to higher density using parents genotyped with a 930K SNP array and pedigree information. We found significant association signals on 28 of 29 chromosomes (P-values: 8.7 × 10 DISCUSSION: These results reveal a mixed architecture of large-effect loci and a polygenic component that consists of multiple smaller-effect loci, suggesting a more complex genetic architecture of Atlantic salmon age at maturity than previously thought. This more complex architecture will have implications for selection on this key trait in aquaculture and for management of wild salmon populations.
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