ReviewNutrients2020
Nutritional Status as a Mediator of Fatigue and Its Underlying Mechanisms in Older People.
Review in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 103 citations in OpenAlex.
- Trial
- Oleoylethanolamide supplementation improves mood and reduces fatigue in veterans with GWI in a 15-week randomized, double-blind, placebo-controlled exploratory clinical trial.Scientific reports · 2026Trial
- Changes in Digestive Health, Satiety and Overall Well-Being after 14 Days of a Multi-Functional GI Primer Supplement.Nutrients · 2024Trial
- The efficacy of integrated hepatitis C virus treatment in relieving fatigue in people who inject drugs: a randomized controlled trial.Substance abuse treatment, prevention, and policy · 2023Trial
- Trial
- Associations between the Global Leadership Initiative on Malnutrition Criteria and quality of life in patients with gastric cancer: A cross-sectional study.Asia-Pacific journal of oncology nursing · 2026Article
- The independent association of nutritional status with quality of life beyond depression, frailty, and loneliness in community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2026Article
- Disparities in fatigue levels and dietary habits between men and women with inflammatory bowel disease: a comparative analysis with a control cohort.European journal of nutrition · 2026Article
- The herbal pair ofFrontiers in nutrition · 2026Article
- Physical activity and nutritional status as mediators in the relationship between mental health and quality of life in older women: a cross-sectional mediation study in northern Iran.BMC geriatrics · 2025Article
- Cumulative effect of intrinsic capacity domains on geriatric syndromes and functionality in older inpatients.BMC geriatrics · 2025Observational
- Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer's mouse model.Biology of sex differences · 2025Article
- Association between dietary micronutrient adequacy index and sleep quality, sleep duration and chronic fatigue in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Current Status and Determinants of Fatigue in Chinese Older Adults Receiving Maintenance Hemodialysis: A Multicentre Cross-Sectional Study.Clinical interventions in aging · 2025Article
- Frailty phenotypes and their association with health consequences: a comparison of different measures.Aging clinical and experimental research · 2024Review
- The associations between dairy product intake, fatigue status, and physical activity among postpartum women in Saudi Arabia: a cross-sectional study.BMC public health · 2024Article
- Identifying Malnutrition Risk in the Elderly: A Single- and Multi-Parameter Approach.Nutrients · 2024Article
- Pityriasis Rosea-Like Eruption following anti-fatigue traditional herbs: Aconitum carmichaelii Debx and Panax Ginseng suspected.BMC complementary medicine and therapies · 2024Article
- Article
- Diet quality from mid to late life and its association with physical frailty in late life in a cohort of Chinese adults.Nutrition journal · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fatigue is an often-neglected symptom but frequently complained of by older people, leading to the inability to continue functioning at a normal level of activity. Fatigue is frequently associated with disease conditions and impacts health status and quality of life. Yet, fatigue cannot generally be completely explained as a consequence of a single disease or pathogenetic mechanism. Indeed, fatigue mirrors the exhaustion of the physiological reserves of an older individual. Despite its clinical relevance, fatigue is typically underestimated by healthcare professionals, mainly because reduced stamina is considered to be an unavoidable corollary of aging. The incomplete knowledge of pathophysiological mechanisms of fatigue and the lack of a gold standard tool for its assessment contribute to the poor appreciation of fatigue in clinical practice. Inadequate nutrition is invoked as one of the mechanisms underlying fatigue. Modifications in food intake and body composition changes seem to influence the perception of fatigue, probably through the mechanisms of inflammation and/or mitochondrial dysfunction. Here, we present an overview on the mechanisms that may mediate fatigue levels in old age, with a special focus on nutrition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.