Evidence map›Paper›PMID 32050628›Full record

ArticleMolecules (Basel, Switzerland)2020

Anticancer Activities of the Quinone-Methide Triterpenes Maytenin and 22-β-hydroxymaytenin Obtained from Cultivated

Camila Hernandes, Lucyene Miguita, Romario Oliveira de Sales, Elisangela de Paula Silva, Pedro Omori Ribeiro de Mendonça, Bruna Lorencini da Silva, Maria de Fatima Guarizo Klingbeil, Monica Beatriz Mathor, Erika Bevilaqua Rangel, Luciana Cavalheiro Marti and 4 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  3. ACS omega · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Camila HernandesAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Lucyene MiguitaDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-2604-5210
Romario Oliveira de SalesAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Elisangela de Paula SilvaAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Pedro Omori Ribeiro de MendonçaAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Bruna Lorencini da SilvaAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.
Maria de Fatima Guarizo KlingbeilNuclear and Energy Research Institute IPEN-CNEN/SP, São Paulo 05508-000, Brazil.ORCID 0000-0002-9989-1653
Monica Beatriz MathorNuclear and Energy Research Institute IPEN-CNEN/SP, São Paulo 05508-000, Brazil.ORCID 0000-0002-7294-9106
Erika Bevilaqua RangelAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0003-0982-2484
Luciana Cavalheiro MartiAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0002-3890-0827
Juliana da Silva CoppedeUnidade de Biotecnologia, Universidade de Ribeirão Preto, Ribeirão Preto 14096-900, Brazil.
Fabio Daumas NunesDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil.ORCID 0000-0002-7785-6785
Ana Maria Soares PereiraUnidade de Biotecnologia, Universidade de Ribeirão Preto, Ribeirão Preto 14096-900, Brazil.ORCID 0000-0002-3478-4718
Patricia SeverinoAlbert Einstein Research and Education Institute, Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil.ORCID 0000-0002-6682-9343
Hospital Israelita Albert Einstein · BRNational Nuclear Energy Commission · BRUniversidade de Ribeirão Preto · BRUniversidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/15431-2
6 · The paper itself

Abstract

Natural triterpenes exhibit a wide range of biological activities. Since this group of secondary metabolites is structurally diverse, effects may vary due to distinct biochemical interactions within biological systems. In this work, we investigated the anticancer-related activities of the quinone-methide triterpene maytenin and its derivative compound 22-β-hydroxymaytenin, obtained from

Indexed as

Acute Kidney InjuryAnimalsAntineoplastic Agents, PhytogenicApoptosisCell Line, TumorDown-RegulationDrug Screening Assays, AntitumorFemaleGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansKeratinocytesMaytenusMice, SCIDMicroRNAsPentacyclic TriterpenesAntineoplastic Agents, PhytogenicMicroRNAsMIRN17 microRNA, humanMIRN20a microRNA, humanPentacyclic TriterpenesPlant ExtractstingenoneTriterpenesmicroRNAquinone-methidesquamous cell carcinomatriterpene

Identifiers

PMID32050628
PMCPMC7038027
OpenAlexW3004695349

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.