ArticleInternational journal of molecular sciences2020
High Dosage Lithium Treatment Induces DNA Damage and p57
Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Modifications on histone tails in psychiatric disorders.EC psychology and psychiatry · 2026Article
- p27Cells · 2025Article
- p57International journal of molecular sciences · 2024Article
- Ecotoxicological Characterization of Lithium as a "Timebomb" in Aquatic Systems: Tadpoles of the South American ToadToxics · 2024Article
- Lithium in Cancer Therapy: Friend or Foe?Cancers · 2023Review
- Lithium Enhances Hippocampal Glucose Metabolism in an In Vitro Mice Model of Alzheimer's Disease.International journal of molecular sciences · 2022Article
- A Beckwith-Wiedemann-AssociatedInternational journal of molecular sciences · 2021Article
- A cancer-associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss-of-function.Molecular oncology · 2021Article
- Overexpression of Phosphoribosyl Pyrophosphate Synthase Enhances Resistance ofFrontiers in plant science · 2021Article
- Regulation of p27Biomolecules · 2020Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lithium salt is the first-line therapeutic option for bipolar disorder and has been proposed as a potential antitumoral drug. The effects of LiCl treatment were investigated in SH-SY5Y, a human neuroblastoma cell line and an in vitro model of dopaminergic neuronal differentiation. LiCl, at the dosage used in psychiatric treatment, does not affect cell proliferation, while at higher doses it delays the SH-SY5Y cell division cycle and for prolonged usage reduces cell viability. Moreover, the ion treatment affects DNA integrity as demonstrated by accumulation of p53 and γH2AX (the phosphorylated form of H2AX histone), two important markers of genome damage. p57
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