Evidence map›Paper›PMID 32050453›Full record

ArticleNutrients2020

Cholesterol-Lowering Action of a Novel Nutraceutical Combination in Uremic Rats: Insights into the Molecular Mechanism in a Hepatoma Cell Line.

Maria Giovanna Lupo, Noemi Biancorosso, Elisa Brilli, Germano Tarantino, Maria Pia Adorni, Greta Vivian, Marika Salvalaio, Stefano Dall'Acqua, Stefania Sut, Cédric Neutel and 5 more

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Towards Personalized Therapy of Aortic Stenosis.Journal of personalized medicine · 2021
    Review
  5. Review
  6. The Modulation of PCSK9 and LDLR by Supercritical COMolecules (Basel, Switzerland) · 2021
    Article
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 3 countries.

Maria Giovanna LupoDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.ORCID 0000-0002-4236-4414
Noemi BiancorossoDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.
Elisa BrilliPharmaNutra S.p.A., 56122, Pisa, Italy.
Germano TarantinoPharmaNutra S.p.A., 56122, Pisa, Italy.
Maria Pia AdorniDipartimento di Scienze degli Alimenti e del Farmaco, Università di Parma, 43100, Parma, Italy.
Greta VivianDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.
Marika SalvalaioDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.
Stefano Dall'AcquaDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.ORCID 0000-0001-8264-6953
Stefania SutDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.
Cédric NeutelLaboratory of Physiopharmacology, Research Unit GENCOR, University of Antwerp, 2610, Antwerp, Belgium.
Haixia ChenTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, 300072, Tianjin, China.ORCID 0000-0002-2596-9622
Alessandro BressanDipartimento di Medicina, Università degli Studi di Padova, 35121, Padova, Italy.
Elisabetta FagginDipartimento di Medicina, Università degli Studi di Padova, 35121, Padova, Italy.
Marcello RattazziDipartimento di Medicina, Università degli Studi di Padova, 35121, Padova, Italy.
Nicola FerriDipartimento di Scienze del Farmaco, Università degli Studi di Padova, 35131, Padova, Italy.ORCID 0000-0001-8898-7441
University of Padua · ITTianjin University · CNUniversity of Antwerp · BEUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Appropriate nutraceutical combinations may represent a valid approach to prevent vascular calcification associated with chronic kidney disease (CKD). In the present study, we tested the effect of a new nutraceutical combination named RenaTris

Indexed as

Dietary SupplementsAcyl Coenzyme AAdenineAnimalsAnticholesteremic AgentsCell Line, TumorCholesterolCysteineHumansHypercholesterolemiaIronMagnesiumMaleRats, Sprague-DawleyReceptors, LDLRenal Insufficiency, Chronic3-hydroxy-3-methylglutaryl-coenzyme AAcyl Coenzyme AAdeninealliinAnticholesteremic AgentsCholesterolCysteineIronMagnesiummagnesium carbonateReceptors, LDLSimvastatincholesterolmevalonate pathwayMK-7PCSK9uremic

Identifiers

PMID32050453
PMCPMC7071245
OpenAlexW3005514129

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.