ArticlePLoS neglected tropical diseases2020
Time-resolved proteomic profile of Amblyomma americanum tick saliva during feeding.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 75 citations in OpenAlex.
- Spotted fever group Rickettsia infection kinetics and cutaneous host response during single tick feeding events.PLoS pathogens · 2026Article
- Chromosome-Scale Atlas ofGenes · 2026Article
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- Cattle Immunization with T7 Phage-Displayed Whole-Tick Antigens ReducesPathogens (Basel, Switzerland) · 2026Article
- IxsS7: A novel biomarker for Ixodes scapularis tick bite exposure in humans.Ticks and tick-borne diseases · 2025Article
- Multi-Omics Technologies Applied to Improve Tick Research.Microorganisms · 2025Review
- Glycine rich proteins of ticks: more than a cement component.Parasitology · 2024Review
- RecombinantPathogens (Basel, Switzerland) · 2024Article
- A tick saliva serpin, IxsS17 inhibits host innate immune system proteases and enhances host colonization by Lyme disease agent.PLoS pathogens · 2024Article
- Changes in saliva protein profile throughout Rhipicephalus microplus blood feeding.Parasites & vectors · 2024Article
- Tick extracellular vesicles in host skin immunity and pathogen transmission.Trends in parasitology · 2023Review
- Rabbits as Animal Models for Anti-Tick Vaccine Development: A Global Scenario.Pathogens (Basel, Switzerland) · 2023Review
- Circulating oxidative stress and acute phase protein levels in horses infested with ticks.Experimental & applied acarology · 2023Article
- A high-quality Ixodes scapularis genome advances tick science.Nature genetics · 2023Article
- Article
- Identification and characterization of proteins that form the inner core Ixodes scapularis tick attachment cement layer.Scientific reports · 2022Article
- A proteomics informed by transcriptomics insight into the proteome of Ornithodoros erraticus adult tick saliva.Parasites & vectors · 2022Article
- Tick Intrastadial Feeding and Its Role on IgE Production in the Murine Model of Alpha-gal Syndrome: The Tick "Transmission" Hypothesis.Frontiers in immunology · 2022Article
- Proteomics informed by transcriptomics for a qualitative and quantitative analysis of the sialoproteome of adult Ornithodoros moubata ticks.Parasites & vectors · 2021Article
- Acquired tick resistance: The trail is hot.Parasite immunology · 2021Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Amblyomma americanum ticks transmit more than a third of human tick-borne disease (TBD) agents in the United States. Tick saliva proteins are critical to success of ticks as vectors of TBD agents, and thus might serve as targets in tick antigen-based vaccines to prevent TBD infections. We describe a systems biology approach to identify, by LC-MS/MS, saliva proteins (tick = 1182, rabbit = 335) that A. americanum ticks likely inject into the host every 24 h during the first 8 days of feeding, and towards the end of feeding. Searching against entries in GenBank grouped tick and rabbit proteins into 27 and 25 functional categories. Aside from housekeeping-like proteins, majority of tick saliva proteins belong to the tick-specific (no homology to non-tick organisms: 32%), protease inhibitors (13%), proteases (8%), glycine-rich proteins (6%) and lipocalins (4%) categories. Global secretion dynamics analysis suggests that majority (74%) of proteins in this study are associated with regulating initial tick feeding functions and transmission of pathogens as they are secreted within 24-48 h of tick attachment. Comparative analysis of the A. americanum tick saliva proteome to five other tick saliva proteomes identified 284 conserved tick saliva proteins: we speculate that these regulate critical tick feeding functions and might serve as tick vaccine antigens. We discuss our findings in the context of understanding A. americanum tick feeding physiology as a means through which we can find effective targets for a vaccine against tick feeding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.