ArticleMedicine2020
D-Dimer level was associated with prognosis in metastatic colorectal cancer: A Chinese patients based cohort study.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Evaluation of treatment for diffuse large B-cell lymphoma using plasma D-dimer levels.Scientific reports · 2025Article
- Article
- The Potential of Integrative Cancer Treatment Using Melatonin and the Challenge of Heterogeneity in Population-Based Studies: A Case Report of Colon Cancer and a Literature Review.Current oncology (Toronto, Ont.) · 2024Review
- The Influence of Cancer Type on Stroke Incidence: A Retrospective Study.Clinical Medicine Insights. Oncology · 2024Article
- The prognostic value of preoperative D-dimer to albumin ratio for overall survival and progression-free survival in colorectal cancer.Frontiers in physiology · 2024Article
- D-dimer, Fibrinogen and Tumor Marker Levels in Patients with benign and Malignant Ovarian Tumors.Asian Pacific journal of cancer prevention : APJCP · 2023Article
- Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer and its predictive value.BMC gastroenterology · 2023Article
- D-dimer to lymphocyte ratio can serve as a potential predictive and prognostic value in colorectal cancer patients with liver metastases.BMC surgery · 2023Article
- Increased D-dimer level was a poor predictor of neuroblastoma, especially in the high-risk group.World journal of surgical oncology · 2023Article
- A novel nomogram based on GD for predicting prognosis in hepatocellular carcinoma.Frontiers in oncology · 2023Article
- Do coagulation or fibrinolysis reflect the disease condition in patients with soft tissue sarcoma?BMC cancer · 2022Article
- Prothrombin time (PT) and CEA as prognostic predictive biomarkers for postoperative recurrence after curative resection in patients with stage I-III colorectal cancer: a retrospective cohort study.Updates in surgery · 2022Article
- Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors.BMC cancer · 2021Article
- High pretreatment plasma D-dimer levels predict poor survival in patients with diffuse large B-cell lymphoma in the real world.Translational cancer research · 2021Article
- Prognostic Role of Preoperative D-dimer Levels in Patients With Stage I-III Colorectal Cancer.Cancer diagnosis & prognosisArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
D-dimer level is a direct measure of activated coagulation and has been used as a biomarker of hypercoagulability. In this study, we aimed to explore the associations between D-dimer level and the clinicopathological features and prognosis in metastatic colorectal cancer (mCRC) patients. One hundred seventy-eight patients diagnosed with mCRC from the Department of General Surgery, Jingmen First People's Hospital from September 2014 to December 2018 were collected. Data of coagulation index was evaluated and survival analysis was performed to identify the biomarker of mCRC. Among 178 cases of colorectal cancer, we found that the value of 0.55 mg/L, 5ng/ml and 40U/ml were cut-off values of D-Dimer, CEA and CA-199 for patients survival, respectively. hypercoagulability was much more frequent in patients aged ≥60 years than <60 years (P < .001) and also in patients with ECOG ≥2 points (P < .001). Moreover, those patients who have CEA >5ng/ml and CA-199>40U/ml had hypercoagulable state (P < .001). There was a significant difference in D-Dimer >0.55 mg/L and D-Dimer ≤0.55 mg/L among the number of metastatic sites (P < .01) and patients with comorbidities (P < .01). Survival analysis showed that patients with D-Dimer >0.55 mg/L have significantly unfavorable overall survival (P = .006) and progressive free survival (P = .011).
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