Evidence map›Paper›PMID 32049864›Full record

Observational studyMedicine2020

First-line treatment failure in childhood acute lymphoblastic leukemia: The polish pediatric leukemia and lymphoma study group experience.

Joanna Zawitkowska, Monika Lejman, Katarzyna Drabko, Agnieszka Zaucha-Prażmo, Marcin Płonowski, Joanna Bulsa, Michał Romiszewski, Agnieszka Mizia-Malarz, Andrzej Kołtan, Katarzyna Derwich and 8 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 5 countries.

Joanna ZawitkowskaDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin.
Monika LejmanDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin.
Katarzyna DrabkoDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin.
Agnieszka Zaucha-PrażmoDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin.
Marcin PłonowskiDepartment of Pediatric Oncology, Hematology, Medical University of Białystok.
Joanna BulsaDepartment of Pediatrics, Hematology and Oncology, Medical University of Zabrze.
Michał RomiszewskiDepartment of Hematology and Pediatrics, Children's Hospital, Warsaw.
Agnieszka Mizia-MalarzDepartment of Pediatric Oncology, Hematology and Chemotherapy, Medical University of Katowice.
Andrzej KołtanDepartment of Pediatrics, Hematology and Oncology, Collegium Medicum of Bydgoszcz.
Katarzyna DerwichDepartment of Pediatric Oncology, Hematology and Transplantology, Medical University of Poznań.
Grażyna KarolczykDepartment of Pediatric Oncology and Hematology, Children's Hospital, Kielce.
Tomasz OciepaDepartment of Pediatrics, Hematology and Oncology, Medical University of Szczecin.
Magdalena ĆwiklińskaDepartment of Pediatric Oncology and Hematology, Children's University Hospital, Kraków.
Joanna TrelińskaDepartment of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Łódź.
Joanna Owoc-LempachDepartment of Pediatric Transplantology, Oncology, Hematology, Medical University of Wrocław.
Maciej NiedźwieckiDepartment of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdańsk.
Aleksandra KiermaszDepartment of Pediatric Hematology and Oncology, Center of Pediatrics and Oncology, Chorzów, Poland.
Jerzy KowalczykDepartment of Pediatric Hematology, Oncology and Transplantology, Medical University of Lublin.
Medical University of Lublin · PLMedical University of Silesia · PLUniwersytecki Szpital Dziecięcy · PLChildren's Hospital · TNChildren's Oncology Group · CHCollegium Medicum in Bydgoszcz · PLGdańsk Medical University · PLLublin Oncology Center · PLMedical University of Białystok · PLMedical University of Lodz · PLPoznan University of Medical Sciences · PLUniversity of Szczecin · PLWroclaw Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to evaluate the risk factors of relapse and treatment-related deaths in acute lymphoblastic leukemia (ALL) in children residing in Poland.A total of 1872 patients with newly diagnosed ALL, treated according to the ALL IC-BFM 2002 protocol in 14 Polish pediatric hematology centers from 2002 to 2012 were included in the study. Three-hundred eighty-four patients experienced treatment failure. The last follow-up was 31 December, 2016.Univariate analysis identified factors in each risk group that were significantly different between children whose treatment failed and those who remained in the first remission. Multivariate analysis demonstrated that only the age of 10 years or over at primary diagnosis in the high-risk group was an adverse prognostic factor. To facilitate the analysis, patients were divided into three groups: relapsed children who survived; relapsed children who died; children without relapse who died due to toxicity.Our analysis showed that age older than 10 years is a particular risk factor for the failure of first-line of treatment, both in terms of relapse and treatment-related mortality.

Indexed as

AdolescentAntineoplastic AgentsChildChild, PreschoolFemaleHumansInfantMalePolandPrecursor Cell Lymphoblastic Leukemia-LymphomaRetrospective StudiesTreatment FailureAntineoplastic Agents

Identifiers

PMID32049864
PMCPMC7035074
OpenAlexW3006572386

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.