SynthesisMedicine2020
Risk factors of haemorrhagic transformation for acute ischaemic stroke in Chinese patients receiving intravenous thrombolysis: A meta-analysis.
Synthesis in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- Volumetric Infarct Size Predicts Secondary Haemorrhagic Transformation of Ischaemic Stroke.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- A bicentric study on the application of dual energy CT for predicting hemorrhagic transformation post endovascular thrombectomy.Scientific reports · 2025Article
- Factors influencing the health behaviors of patients with ischemic stroke from a social-ecological perspective: a cross-sectional study.BMC public health · 2025Article
- Machine learning, clinical-radiomics approach with HIM for hemorrhagic transformation prediction after thrombectomy and treatment.Frontiers in neurology · 2025Article
- Piperine protects against cerebral ischemic injury by regulating the Caspase-1-mediated pyroptosis pathway.Frontiers in pharmacology · 2025Article
- Evaluating the interaction between hemorrhagic transformation and cerebral edema on functional outcome after ischemic stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2024Article
- Frequency, Severity, Risk Factors, and Outcome of Hemorrhagic Transformation in Anterior and Posterior Stroke.Journal of clinical medicine · 2024Article
- The value of CT-based radiomics in predicting hemorrhagic transformation in acute ischemic stroke patients without recanalization therapy.Frontiers in neurology · 2024Article
- Prediction factors and clinical significance of different types of hemorrhagic transformation after intravenous thrombolysis.European journal of medical research · 2023Article
- Prediction of hemorrhagic transformation via pre-treatment CT radiomics in acute ischemic stroke patients receiving endovascular therapy.The British journal of radiology · 2023Article
- Predictive role of pre-thrombolytic hs-CRP on the safety and efficacy of intravenous thrombolysis in acute ischemic stroke.BMC neurology · 2023Article
- Early Hemorrhagic Transformation after Reperfusion Therapy in Patients with Acute Ischemic Stroke: Analysis of Risk Factors and Predictors.Brain sciences · 2023Article
- Analysis of influencing factors of hemorrhagic transformation in patients with large vessel occlusion stroke after mechanical thrombectomy.American journal of translational research · 2023Article
- Case series of intravenous thrombolysis for acute ischemic stroke in confirmed COVID-19 patients: single-centre experience.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022Article
- RNA-seq analysis of ischemia stroke and normal brain in a tree shrew model with or without type 2 diabetes mellitus.Metabolic brain disease · 2021Article
- Hemorrhagic Transformation After Ischemic Stroke: Mechanisms and Management.Frontiers in neurology · 2021Review
- A Review of Risk Factors and Predictors for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.International journal of vascular medicine · 2021Review
- Identification of Predictors for Hemorrhagic Transformation in Patients with Acute Ischemic Stroke After Endovascular Therapy Using the Decision Tree Model.Clinical interventions in aging · 2020Article
- Intracranial Bleeding After Reperfusion Therapy in Acute Ischemic Stroke.Frontiers in neurology · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the risk factors related to hemorrhagic transformation in Chinese patients with acute ischemic stroke treated with intravenous thrombolysis.
methodsStudies published in different languages were retrieved by systematically searching PubMed, EMBASE, Vip, CNKI, and WanFang Data from the establishment of the library to December 31, 2018, as well as manually examining the references of the original articles. The outcome measures of efficacy covered risk factors. Safety evaluation was measured by relative ratio of complications.
resultsA total of 36 studies involving 5597 participants were covered in this meta-analysis. The results indicated that age [WMD = 2.44, 95% CI (1.39,3.48)], male [OR = 1.21, 95% CI (1.02, 1.44)], diabetes [OR = 2.05, 95%CI (1.72,2.44)], atrial fibrillation [OR = 2.85, 95%CI (2.40, 3.39)], previous stroke [OR = 1.8, 95%CI (1.33, 2.44)], onset to treatment time (OTT) [WMD = 3.74, 95%CI (2.91, 4.58)], National Institute of Health stroke scale scores (NIHSS) [WMD = 4.17, 95% CI (3.37, 4.97)], infarct size [WMD = 4.11, 95% CI (3.15, 5.37)], ischemic signs of computed tomography (CT) [OR = 3.49, 95%CI (2.47, 4.93)] were associated with increased risk of hemorrhagic transformation after intravenous thrombolysis.
conclusionThe systematic review showed that male, age, diabetes, NIHSS, OTT, atrial fibrillation, post stroke, infarct size, and ischemic signs of CT were significantly correlated with hemorrhagic transformation (HT). PROSPERO REGISTRATION NUMBER: CRD42019127499.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.