Evidence map›Paper›PMID 32049584›Full record

ArticleMolecular biology of the cell2020

Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes.

Melissa Crawford, Nancy Liu, Elahe Mahdipour, Kevin Barr, Bryan Heit, Lina Dagnino

Open access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Melissa CrawfordDepartment of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, University of Western Ontario, London, ON N6G 2C4, Canada.
Nancy LiuDepartment of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, University of Western Ontario, London, ON N6G 2C4, Canada.
Elahe MahdipourDepartment of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, University of Western Ontario, London, ON N6G 2C4, Canada.
Kevin BarrDepartment of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, University of Western Ontario, London, ON N6G 2C4, Canada.
Bryan HeitDepartment of Microbiology and Immunology and Robarts Research Institute, University of Western Ontario, London, ON N6G 2C4, Canada.
Lina DagninoDepartment of Physiology and Pharmacology, Children's Health Research Institute and Lawson Health Research Institute, University of Western Ontario, London, ON N6G 2C4, Canada.
Western University · CAChildren’s Health Research Institute · CALawson Health Research Institute · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanosomes are melanin-containing organelles that provide pigmentation and protection from solar UV radiation to the skin. In melanocytes, melanosomes mature and traffic to dendritic tips, where they are transferred to adjacent epidermal keratinocytes through pathways that involve microtubule networks and the actin cytoskeleton. However, the role of scaffold proteins in these processes is poorly understood. Integrin-linked kinase (ILK) is a scaffold protein that regulates microtubule stability and F-actin dynamics. Here we show that ILK is necessary for normal trafficking of melanosomes along microtubule tracks. In the absence of ILK, immature melanosomes are not retained in perinuclear regions, and mature melanosome trafficking along microtubule tracks is impaired. These deficits can be attenuated by microtubule stabilization. Microtubules are also necessary for the formation of dendrites in melanocytes, and

Indexed as

AnimalsCells, CulturedDendritesGenes, ReporterGlycogen Synthase Kinase 3Intercellular Signaling Peptides and ProteinsKeratinocytesMelaninsMelanocytesMelanosomesMiceMicrotubulesNerve Tissue ProteinsProtein Serine-Threonine Kinasesrab7 GTP-Binding Proteinsrab GTP-Binding Proteinscollapsin response mediator protein-2Glycogen Synthase Kinase 3Intercellular Signaling Peptides and ProteinsMelaninsNerve Tissue ProteinsProtein Serine-Threonine Kinasesrab7 GTP-Binding Proteinsrab GTP-Binding ProteinsRecombinant ProteinsScaffold Protein ILK

Identifiers

PMID32049584
PMCPMC7185957
OpenAlexW3005547726

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.