Evidence map›Paper›PMID 32049548›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Interferon-γ inhibits sirtuin 6 gene expression in intestinal epithelial cells through a

Fangyi Liu, Xiao Wang, Hua Geng, Heng-Fu Bu, Peng Wang, Isabelle G De Plaen, Hong Yang, Jiaming Qian, Xiao-Di Tan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 64% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Fangyi LiuDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Xiao WangDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Hua GengDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Heng-Fu BuDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Peng WangDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Isabelle G De PlaenDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Hong YangDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Jiaming QianDepartment of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Xiao-Di TanDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Center for Intestinal and Liver Inflammation Research, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Northwestern University · USChinese Academy of Medical Sciences & Peking Union Medical College · CNLurie Children's Hospital · US

Funding

Role of the intestinal microvasculature in necrotizing enterocolitisR01DK116568 · NIDDK · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI DE PLAEN, ISABELLE G · 2019 to 2023
$2.7M
Surgical studies of gut epithelial apoptosis-initiated critical illnessR01GM117628 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2016 to 2019
$1.9M
Mechanisms underlying disruption of intestinal epithelial barrier in critical illnessR01GM122406 · NIGMS · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI TAN, XIAO-DI · 2017 to 2018
$594k
Pathogenesis of sepsis-induced dysfunction of innate immunityI01BX004120 · VA · JESSE BROWN VA MEDICAL CENTER · PI TAN, XIAO-DI · 2018 to 2022
–
BLRD VA I01 BX001690BLRD VA I01 BX004120NIDDK NIH HHS R01 DK116568NIGMS NIH HHS R01 GM117628NIGMS NIH HHS R01 GM122406
6 · The paper itself

Abstract

Sirtuin 6 (Sirt6) is predominantly expressed in epithelial cells in intestinal crypts. It plays an important role in protecting intestinal epithelial cells against inflammatory injury. Previously, we found that colitis is associated with the downregulation of Sirt6 protein in the intestines. Here, we report that murine interferon-γ (Ifnγ) inhibits Sirt6 protein but not mRNA expression in young adult mouse colonocytes (YAMC, a mouse colonic epithelial cell line) in a dose- and time-dependent manner. Using microRNA array analysis, we showed that Ifnγ induces expression of

Indexed as

AnimalsCell LineEpithelial CellsGene ExpressionInflammationInterferon-gammaIntestinal MucosaIntestinesMicroRNAsSirtuinsInterferon-gammaMicroRNAsSirt6 protein, mouseSirtuinscell signalinginflammationintestinal epithelial cellsmicroRNAs and gene expression

Identifiers

PMID32049548
PMCPMC7191422
OpenAlexW3005911680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.