Evidence map›Paper›PMID 32049520›Full record

ArticleJournal of natural products2020

The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster.

Wenqing Zhou, Haoyu Liang, Xiangjing Qin, Danfeng Cao, Xiangcheng Zhu, Jianhua Ju, Ben Shen, Yanwen Duan, Yong Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of natural products, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. A novelFrontiers in microbiology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Wenqing ZhouXiangya International Academy of Translational Medicine at Central South University , Changsha , Hunan 410013 , People's Republic of China.
Haoyu LiangXiangya International Academy of Translational Medicine at Central South University , Changsha , Hunan 410013 , People's Republic of China.
Xiangjing QinCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , People's Republic of China.ORCID 0000-0001-6708-1368
Danfeng CaoXiangya International Academy of Translational Medicine at Central South University , Changsha , Hunan 410013 , People's Republic of China.
Xiangcheng ZhuXiangya International Academy of Translational Medicine at Central South University , Changsha , Hunan 410013 , People's Republic of China.
Jianhua JuCAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia, RNAM Center for Marine Microbiology , South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301 , People's Republic of China.ORCID 0000-0001-7712-8027
Ben ShenORCID 0000-0002-9750-5982
Yanwen DuanXiangya International Academy of Translational Medicine at Central South University , Changsha , Hunan 410013 , People's Republic of China.
Yong HuangXiangya International Academy of Translational Medicine at Central South University , Changsha , Hunan 410013 , People's Republic of China.ORCID 0000-0002-3163-1716
Central South University · CNChinese Academy of Sciences · CN

Funding

Mining Actinomycetal Genomes for Natural Product Discovery and BiosynthesisR35GM134954 · NIGMS · UNIVERSITY OF FLORIDA · PI Ben Shen · 2020 to 2026
$5.1M
NIGMS NIH HHS R35 GM134954
6 · The paper itself

Abstract

Dithiolopyrrolones are microbial natural products containing a disulfide or thiosulfonate bridge embedded in a unique bicyclic structure. By interfering with zinc ion homeostasis in living cells, they show strong antibacterial activity against a variety of bacterial pathogens, as well as potent cytotoxicity against human cancer cells. In the current study, two new dithiolopyrrolones, pyrroloformamide C (

Indexed as

Anti-Bacterial AgentsBacterial ProteinsBiological ProductsFormamidesHeterocyclic Compounds, 2-RingHumansLactamsMolecular StructureMultigene FamilyPeptide SynthasesStreptomycesAnti-Bacterial AgentsBacterial ProteinsBiological ProductsFormamidesHeterocyclic Compounds, 2-RingholomycinLactamsN-(4,5-dihydro-5-oxo-1,2-dithiolo(4,3-b)pyrrol-6-yl)-N-methylformamidenon-ribosomal peptide synthasePeptide Synthases

Identifiers

PMID32049520
PMCPMC7577424
OpenAlexW3006442053

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.