ArticleRevista da Sociedade Brasileira de Medicina Tropical2020
Relationship between antifungal susceptibility profile and virulence factors in Candida albicans isolated from nail specimens.
Article in Revista da Sociedade Brasileira de Medicina Tropical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Virulence factors of Candida spp. isolated from COVID-19 patients: hydrolytic enzyme activity and biofilm formation.BMC microbiology · 2025Article
- Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis.Scientific reports · 2025Article
- Phenotypic Impact and Multivariable Assessment of Antifungal Susceptibility inJournal of fungi (Basel, Switzerland) · 2025Article
- Superficial Candidiasis: Cluster Analysis of Species Distribution and Their Antifungal Susceptibility In Vitro.Journal of fungi (Basel, Switzerland) · 2025Article
- Addressing the silent threat: managing invasiveFrontiers in pediatrics · 2025Review
- Characterization of Candida species isolated from clinical specimens: insights into virulence traits, antifungal resistance and molecular profiles.BMC microbiology · 2024Article
- Elucidation of the mechanisms of fluconazole resistance and repurposing treatment options against urinary Candida spp. isolated from hospitalized patients in Alexandria, Egypt.BMC microbiology · 2024Article
- Phenotypic and genotypic characterization of virulence markers and antifungal susceptibility of oral Candida species from diabetic and non-diabetic hemodialysis patients.BMC oral health · 2023Article
- Evaluation of virulence factors and azole resistance mechanisms ofIranian journal of microbiology · 2023Article
- Antifungal Resistance of ClinicalIranian journal of public health · 2023Review
- Biofilm Formation and Aspartyl Proteinase Activity and Their Association with Azole Resistance AmongInfection and drug resistance · 2023Article
- Performance of Two Extracts Derived from Propolis on Mature Biofilm Produced byAntibiotics (Basel, Switzerland) · 2022Article
- Itraconazole-Loaded Ufasomes: Evaluation, Characterization, and Anti-Fungal Activity againstPharmaceutics · 2022Article
- Article
- The effect of antifungal resistance development on the virulence of Candida species.FEMS yeast research · 2022Article
- Correlation Between Drug Resistance and Virulence ofInfection and drug resistance · 2022Article
- Article
- Characterization ofFrontiers in molecular biosciences · 2022Article
- Virulence and Antifungal Susceptibility ofAntibiotics (Basel, Switzerland) · 2021Article
- Virulence Factors and Antifungal Susceptibility in Candida Species Isolated from Dermatomycosis Patients.Mycopathologia · 2021Article
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8 authors.
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Abstract
introductionThe aim of this study was to evaluate some virulence factors in Candida albicans isolates from patients with onychomycosis and determine the correlation between these factors and the antifungal resistance profile.
methodsSeventy species of C. albicans were confirmed using polymerase chain reaction amplification of the HWP1 gene. According to the Clinical & Laboratory Standards Institute guidelines, the susceptibility profile of four antifungal agents was investigated, and the production of aspartyl protease, phospholipase, haemolysin, and biofilm was determined. The correlation between these profiles was also investigated.
resultsThe isolates indicated different levels of resistance and production of virulence factors. Significant correlations were observed between the minimum inhibitory concentration (MIC) of fluconazole/itraconazole and biofilm production, between phospholipase production and fluconazole/itraconazole MIC, and between fluconazole MIC and hemolytic activity in C. albicans isolates. The results also showed significant correlations between phospholipase activity and biofilm production.
conclusionsOur findings will contribute to a better understanding of the pathogenesis of C. albicans and characterize the relationship between virulence factors and antifungal resistance, which may suggest new therapeutic strategies considering the possible involvement of the virulence mechanism in the effectiveness of treatment.
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