ArticleCancer cell2020
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas.
Abstract readComparative Study
In one paragraph
Article in Cancer cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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70citing papers in PubMed
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Who cites it
70 citing papers in PubMed.
- Immunotherapy for Diffuse Midline Glioma: From Preclinical Modeling to Clinical Translation.Cancers · 2026Review
- Pan-cancer atlas of cellular architecture reveals a nearest-neighbour distance-associated biomechanical-immune axis involving CD4+ memory T cells.Clinical and translational medicine · 2026Article
- Immunohistochemical characterization of neural stem cells in brains of adult brachycephalic dogs in comparison with canine oligodendroglioma cells.The Journal of veterinary medical science · 2026Article
- Leveraging Dog Models to Uncover Human Cancer Insights.Research square · 2026Article
- FcεRγI promotes canine CD8 chimeric antigen receptor T cell cytotoxicity through a Syk-NF-κB axis.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Conserved Pathways, Divergent Outcomes: A Cross-Species Genomic Perspective on the Cancer-Neurodegeneration Paradox.International journal of molecular sciences · 2026Review
- Development of a high-grade glioma preclinical surgery model using an inducible KRAS/TP53 Oncopig.Frontiers in oncology · 2026Article
- Translational Models for Glioblastoma: Revolutionizing Drug Development and Personalized Medicine through Clinical Insights.Theranostics · 2026Review
- Diagnostic and prognostic values of differentially expressed genes in canine mammary carcinoma: An integrated bioinformatics analysis.PloS one · 2026Article
- Invasive properties of patient-derived glioblastoma cells after reversible electroporationRadiology and oncology · 2025Article
- Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors.Journal for immunotherapy of cancer · 2025Article
- Adapting Laser Interstitial Thermal Therapy for the Treatment of Naturally Occurring Intracranial Tumors in Dogs.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Article
- Opportunities in the translational pipeline for pediatric brain cancer therapies.Pediatric research · 2025Review
- Barking up the right tree: Immune checkpoint signatures of human and dog cancers.PLoS computational biology · 2025Article
- Multi-modal and Multi-view Cervical Spondylosis Imaging Dataset.Scientific data · 2025Article
- Differential gene expression analysis in French bulldog high grade oligodendroglioma: breed-associated differences in tumor and tumor microenvironment gene expression.Companion animal health and genetics · 2025Article
- The development of a canine single-chain phage antibody library to isolate recombinant antibodies for use in translational cancer research.Cell reports methods · 2025Article
- Maximizing the dual benefit of pet dogs in cancer trials.Nature reviews. Cancer · 2025Article
- A case of anaplastic oligodendroglioma in a rabbit (Oryctolagus cuniculus).The Journal of veterinary medical science · 2025Article
- Oligodendroglioma pseudoprogression after radiotherapy in a dog: a case report.Frontiers in veterinary science · 2025Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
31 authors.
Samirkumar B AminThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Kevin J AndersonThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
C Elizabeth BoudreauDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Emmanuel Martinez-LedesmaTecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Avenue Morones Prieto 3000, Monterrey, Nuevo Leon 64710, Mexico; Department of Neuro-Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Emre KocakavukThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; DKFZ Division of Translational Neurooncology at the West German Cancer Center (WTZ), German Cancer Consortium (DKTK) Partner Site & Department of Neurosurgery, University Hospital Essen, Essen, Germany.
Kevin C JohnsonThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Floris P BarthelThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Frederick S VarnThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Cynthia KassabDepartment of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Xiaoyang LingDepartment of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Hoon KimThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Mary BarterThe Jackson Laboratory, Bar Harbor, ME 04609, USA.
Ching C LauThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA; Connecticut Children's Medical Center, Hartford, CT 06106, USA; University of Connecticut School of Medicine, Farmington, CT 06032, USA.
Chew Yee NganThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Margaret ChapmanThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA.
Jennifer W KoehlerDepartment of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, USA.
James P LongDepartment of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Biostatistics, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Andrew D MillerDepartment of Biomedical Sciences, Section of Anatomic Pathology, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
C Ryan MillerDepartments of Pathology and Laboratory Medicine, Neurology, and Pharmacology, Lineberger Comprehensive Cancer Center and Neuroscience Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
Brian F PorterDepartment of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA.
Daniel R RissiDepartment of Pathology and Athens Veterinary Diagnostic Laboratory, College of Veterinary Medicine, University of Georgia, Athens, GA, USA.
Christina MazckoComparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Amy K LeBlancComparative Oncology Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Peter J DickinsonDepartment of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, CA, USA.
Rebecca A PackerDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
Amanda R TaylorAuburn University College of Veterinary Medicine, Auburn, AL, USA.
John H RossmeislVA-MD College of Veterinary Medicine, Blacksburg, VA, USA.
Kevin D WoolardDepartment of Surgical and Radiological Sciences, UC Davis School of Veterinary Medicine, Davis, CA, USA.
Amy B HeimbergerDepartment of Neurosurgery, the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Jonathan M LevineDepartment of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
Roel G W VerhaakThe Jackson Laboratory for Genomic Medicine, Farmington, CT 06032, USA. Electronic address: roel.verhaak@jax.org.
Funding
Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8MShared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI William Carl Skarnes · 1985 to 2026
$61.9MSub-component for Institution # 16-01848 Novel moleculary targeted therapy of GBMP01CA207206 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ROSSMEISL, JOHN HENRY · 2017 to 2021
$9.0MModulation of Microglia and T Cell Interactions in Malignant GliomaR01CA120813 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, GANESH · 2007 to 2025
$4.7MDNA TOPOISOMERASES AS TARGET OF ACTION OF ANTICANCER DRUGSZ01BC006161 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI POMMIER, YVES · 1996 to 2008
$1.5M(PQ #4) Single cell barcoding for studies of study clonal evolution in glioblastomaR01CA190121 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SULMAN, ERIK, VERHAAK, ROEL GW · 2014 to 2017
$1.4MComparative Brain Tumor ConsortiumZIABC011696 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI LEBLANC, AMY · 2016 to 2025
$859kGenetic and Epigenetic Strategies for the Acquisition of Telomere Maintenance in Human Cancer CellsK99CA226387 · NCI · JACKSON LABORATORY · PI BARTHEL, FLORIS · 2018 to 2021
$250kIntramural NIH HHS Z01 BC006161NCI NIH HHS K99 CA226387NCI NIH HHS P01 CA207206NCI NIH HHS P30 CA016672NCI NIH HHS P30 CA034196NCI NIH HHS R01 CA120813NCI NIH HHS R01 CA190121
Abstract
Sporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of human pediatric and adult gliomas to characterize evolutionarily conserved mammalian mutational processes in gliomagenesis. Employing whole-genome, exome, transcriptome, and methylation sequencing of 83 canine gliomas, we found alterations shared between canine and human gliomas such as the receptor tyrosine kinases, TP53 and cell-cycle pathways, and IDH1 R132. Canine gliomas showed high similarity with human pediatric gliomas per robust aneuploidy, mutational rates, relative timing of mutations, and DNA-methylation patterns. Our cross-species comparative genomic analysis provides unique insights into glioma etiology and the chronology of glioma-causing somatic alterations.
Indexed as
AnimalsBrain NeoplasmsDNA MethylationDogsExomeGliomaHumansIsocitrate DehydrogenaseMutationTumor Suppressor Protein p53Isocitrate DehydrogenaseTumor Suppressor Protein p53adult gliomacanine gliomacomparative genomicscomparative oncologycomputational biologylife historymutagenesispediatric glioma
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