Evidence map›Paper›PMID 32049043›Full record

ArticleCancer cell2020

Unraveling the Signaling Balance of Activation and Exhaustion of CAR T Cells.

Irene Scarfò, Marcela V Maus

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cancer cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Irene ScarfòCellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA.
Marcela V MausCellular Immunotherapy Program, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA; Harvard Medical School, Boston, MA 02115, USA. Electronic address: mvmaus@mgh.harvard.edu.
Harvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CAR T cells with different costimulation domains have proven clinical efficacy in leukemia and lymphoma but have different kinetics of activation, antigen sensitivity, and susceptibility to exhaustion. Two recent studies identified that these functions are shaped by a balance among opposing signaling complexes and transcription factors competing for binding motifs.

Indexed as

LymphomaReceptors, Chimeric AntigenHumansProtein Tyrosine Phosphatase, Non-Receptor Type 6Signal TransductionT-LymphocytesProtein Tyrosine Phosphatase, Non-Receptor Type 6PTPN6 protein, humanReceptors, Chimeric Antigen

Identifiers

PMID32049043
OpenAlexW3006226916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.