ArticleCell reports2020
Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Eye-specific drive and binocular suppression in mouse visual cortex during critical period development.bioRxiv : the preprint server for biology · 2026Article
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- Ethological learning during the critical period resets synaptic setpoints in mouse binocular visual cortex.Neuron · 2026Article
- CRISPR inhibition of activity-dependent Arc expression in the adult mouse brain has limited effects on plasticity in visual cortex and nucleus accumbens.bioRxiv : the preprint server for biology · 2026Article
- Binocular Circuitry as a Model for Understanding Experience-Dependent Circuit Development across the Mammalian Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Recent Advances in the Molecular Mechanisms of Ocular Dominance Plasticity in the Visual Cortex.Neuroscience bulletin · 2025Review
- "Arc - A viral vector of memory and synaptic plasticity".Current opinion in neurobiology · 2025Review
- Local connections among excitatory neurons underlie characteristics of enriched environment exposure-induced neuronal response modulation in layers 2/3 of the mouse V1.Frontiers in systems neuroscience · 2025Article
- Widespread and Multifaceted Binocular Integration in the Mouse Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Extensive topographic remapping and functional sharpening in the adult rat visual pathway upon first visual experience.PLoS biology · 2023Article
- Monocular deprivation during the critical period alters neuronal tuning and the composition of visual circuitry.PLoS biology · 2023Article
- Neural circuits for binocular vision: Ocular dominance, interocular matching, and disparity selectivity.Frontiers in neural circuits · 2023Review
- Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.Current biology : CB · 2022Article
- Roles of visually evoked and spontaneous activity in the development of retinal direction selectivity maps.Trends in neurosciences · 2022Review
- The Development of Receptive Field Tuning Properties in Mouse Binocular Primary Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Chronic Monocular Deprivation Reveals MMP9-Dependent and -Independent Aspects of Murine Visual System Plasticity.International journal of molecular sciences · 2022Article
- The influence of spontaneous and visual activity on the development of direction selectivity maps in mouse retina.Cell reports · 2022Article
- Functional Deficits and Structural Changes Associated With the Visual Attention Network During Resting State in Adult Strabismic and Anisometropic Amblyopes.Frontiers in human neuroscience · 2022Article
- Balanced Enhancements of Synaptic Excitation and Inhibition Underlie Developmental Maturation of Receptive Fields in the Mouse Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Vision is required for the formation of binocular neurons prior to the classical critical period.Current biology : CB · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The development of neuronal circuits requires both hard-wired gene expression and experience-dependent plasticity. Sensory processing, such as binocular vision, is especially sensitive to perturbations of experience. We investigated the experience-dependent development of the binocular visual cortex at single-cell resolution by using two-photon calcium imaging in awake mice. At eye-opening, the majority of visually responsive neurons are monocular. Binocular neurons emerge later with visual experience and acquire distinct visual response properties. Surprisingly, rather than mirroring the effects of visual deprivation, mice that lack the plasticity gene Arc show increased numbers of binocular neurons and a shift in ocular dominance during development. Strikingly, acutely removing Arc in the adult binocular visual cortex also increases the number of binocular neurons, suggesting that the maintenance of binocular circuits requires ongoing plasticity. Thus, experience-dependent plasticity is critical for the development and maintenance of circuits required to process binocular vision.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.