ArticleCell reports2020
NAD
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06629636 (Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity and IVF Success Rate in Patients Who Have Experienced IVF Failures.), which is not on this map. Cited by 183 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 1 pooled it
20.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity and IVF Success Rate in Patients Who Have Experienced IVF Failures.
Who cites it
183 citing papers in PubMed, 1 synthesis or guideline pooled it, 305 citations in OpenAlex.
- NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis.Journal of assisted reproduction and genetics · 2026Pooled it
- Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Scientific reports · 2022Trial
- Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.Journal of the International Society of Sports Nutrition · 2021Trial
- Metabolic regulation of oocyte maturation and early embryo development in mammals.Life metabolism · 2026Review
- Novel multi-omic biomarkers to combat oocyte and ovarian aging.GeroScience · 2026Article
- Regional organization of nutrient absorption across the small intestine.Nature reviews. Gastroenterology & hepatology · 2026Review
- The Meiotic Spindle, Mechanisms of Chromosome Segregation and Aneuploidy in Aging Human Oocytes: An Update Review.Medicina (Kaunas, Lithuania) · 2026Review
- Endocrine and Molecular Mechanisms of Oocyte Aging: From Gonadotropin Signaling to Metabolic and Microenvironmental Dysfunction.Current issues in molecular biology · 2026Review
- Maternal age as a driver of genome instability: mechanisms linking aneuploidy, mutagenesis and mitochondrial dysfunction.Archives of toxicology · 2026Review
- Metabolic imaging for gamete and embryo assessment through advanced microscopy technologies: a novel avenue for artificial intelligence?Human reproduction (Oxford, England) · 2026Review
- Review
- Reprogramming senescent granulosa cells for germ-cell generation.Science China. Life sciences · 2026Article
- Tryptophan metabolism: A hidden regulator of female reproductive health beyond fertility.Chinese medical journal · 2026Review
- Crosstalk collapse: mitochondria-centric organelle network disruption in ovarian aging.Cell communication and signaling : CCS · 2026Review
- Exfoliated kidney cells from urine for non-invasive kidney transplant monitoring: A potential opportunity?Clinical and experimental nephrology · 2026Review
- Cuproptosis causes meiotic metaphase I arrest by disrupting mitochondrial functions in oocytes.Cell death discovery · 2026Article
- Chromatin- and actin-mediated mitochondrial streaming leads to patterning of mitochondrial distribution in oocytes.Nature communications · 2026Article
- Reproductive Fitness and the Links to Chronic Disease and Systemic Aging.Physiology (Bethesda, Md.) · 2026Review
- SIRT7 links H3K36ac epigenetic regulation with genome maintenance in the mouse testis.Nature communications · 2026Article
- OGDH mediates α-ketoglutarate-induced follicular development and antioxidative response by interacting with CAT/SOD2.Biological research · 2026Article
123 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
34 authors at 7 institutions in 4 countries.
Michael J BertoldoSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Dave R ListijonoSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Wing-Hong Jonathan HoSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia; School of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Angelique H RiepsamenSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Dale M GossSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Dulama RichaniSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Xing L JinHuman Reproduction Unit, Kolling Institute, Sydney Medical School, University of Sydney, St Leonards, NSW, Australia.
Saabah MahbubARC Centre of Excellence in Nanoscale Biophotonics, UNSW Sydney, NSW, Australia.
Jared M CampbellARC Centre of Excellence in Nanoscale Biophotonics, UNSW Sydney, NSW, Australia.
Abbas HabibalahiARC Centre of Excellence in Nanoscale Biophotonics, UNSW Sydney, NSW, Australia.
Wei-Guo Nicholas LohSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Neil A YoungsonSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Jayanthi ManiamSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Ashley S A WongSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Kaisa SelesniemiPaul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston MA, USA; Jumpstart Fertility Pty Ltd., Sydney, NSW, Australia.
Sonia BustamanteBioanalytical Mass Spectrometry Facility, Mark Wainwright Analytical Centre, UNSW Sydney, Sydney, NSW, Australia.
Catherine LiSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Yiqing ZhaoSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Maria B MarinovaSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Lynn-Jee KimSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Laurin LauSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Rachael M WuGraduate Entry Medical School, University of Limerick, Limerick, Republic of Ireland.
A Stefanie MikolaizakNeuroscience Research Australia, Randwick, NSW, Australia.
Toshiyuki ArakiDepartment of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
David G Le CouteurANZAC Medical Research Institute, University of Sydney, Concord, NSW, Australia.
Nigel TurnerSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Margaret J MorrisSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia.
Kirsty A WaltersSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Ewa GoldysARC Centre of Excellence in Nanoscale Biophotonics, UNSW Sydney, NSW, Australia.
Christopher O'NeillHuman Reproduction Unit, Kolling Institute, Sydney Medical School, University of Sydney, St Leonards, NSW, Australia.
Robert B GilchristSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
David A SinclairSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia; Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston MA, USA. Electronic address: david_sinclair@hms.harvard.edu.
Hayden A HomerSchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia; Christopher Chen Oocyte Biology Laboratory, University of Queensland Centre for Clinical Research, Royal Brisbane & Women's Hospital, Herston, QLD, Australia. Electronic address: h.homer@uq.edu.au.
Lindsay E WuSchool of Medical Sciences, UNSW Sydney, Sydney, NSW, Australia. Electronic address: lindsay.wu@unsw.edu.au.
UNSW Sydney · AUThe University of Sydney · AUHarvard University · USNational Center of Neurology and Psychiatry · JPNeuroscience Research Australia · AUThe University of Queensland · AUUniversity of Limerick · IE
Funding
Uncovering the Human SecretomeDP1AG058605 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2017 to 2021
$5.9MRole of Sgs1 DNA helicase in telomere maintenanceR01AG019719 · NIA · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI SINCLAIR, DAVID A. · 2001 to 2022
$5.3MSIRT1 as a regulator of health and lifespan of mammalsR37AG028730 · NIA · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2012 to 2021
$4.1MElucidating mechanisms of SIRT1 activationR01DK100263 · NIDDK · HARVARD MEDICAL SCHOOL · PI SINCLAIR, DAVID A. · 2016 to 2020
$2.5MNIA NIH HHS DP1 AG058605NIA NIH HHS R01 AG019719NIA NIH HHS R37 AG028730NIDDK NIH HHS R01 DK100263
Abstract
Reproductive aging in female mammals is an irreversible process associated with declining oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of oocyte quality with age accompanies declining levels of the prominent metabolic cofactor nicotinamide adenine dinucleotide (NAD
Indexed as
AgingAnimalsFemaleFertilityMiceMice, TransgenicNADNADagingembryo developmentfemale fertilityinfertilityin vitro fertilizationnicotinamide adenine dinucleotide (NAD+)nicotinamide mononucleotide (NMN)oocytereproductive agingSIRT2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT06629636ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.