ArticleeLife2020
Developmental variability channels mouse molar evolution.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Toward mechanisms underlying the developmental hourglass: evolvability and phylotypic conservation.EvoDevo · 2025Review
- Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars.bioRxiv : the preprint server for biology · 2025Article
- Six million years of vole dental evolution shaped by tooth development.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Stability in gene expression and body-plan development leads to evolutionary conservation.EvoDevo · 2023Article
- Article
- Wild versus lab house mice: Effects of age, diet, and genetics on molar geometry and topography.Journal of anatomy · 2022Article
- Timing of Mouse Molar Formation Is Independent of Jaw Length Including Retromolar Space.Journal of developmental biology · 2021Article
- Genetic structure in Orkney island mice: isolation promotes morphological diversification.Heredity · 2021Article
- Exerting an influence on evolution.eLife · 2020Article
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9 authors.
Funding
Abstract
Do developmental systems preferentially produce certain types of variation that orient phenotypic evolution along preferred directions? At different scales, from the intra-population to the interspecific, the murine first upper molar shows repeated anterior elongation. Using a novel quantitative approach to compare the development of two mouse strains with short or long molars, we identified temporal, spatial and functional differences in tooth signaling center activity, that arise from differential tuning of the activation-inhibition mechanisms underlying tooth patterning. By tracing their fate, we could explain why only the upper first molar reacts via elongation of its anterior part. Despite a lack of genetic variation, individuals of the elongated strain varied in tooth length and the temporal dynamics of their signaling centers, highlighting the intrinsic instability of the upper molar developmental system. Collectively, these results reveal the variational properties of murine molar development that drive morphological evolution along a line of least resistance.
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Registered trials
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