Evidence map›Paper›PMID 32048834›Full record

ArticleAnalytical chemistry2020

Collision Cross Sections of Charge-Reduced Proteins and Protein Complexes: A Database for Collision Cross Section Calibration.

Alyssa Q Stiving, Benjamin J Jones, Jakub Ujma, Kevin Giles, Vicki H Wysocki

Abstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Four IgG Antibodies and Protein G Are Shapeshifters.International journal of molecular sciences · 2026
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  11. Evaluation of a Commercial TIMS-Q-TOF Platform for Native Mass Spectrometry.Journal of the American Society for Mass Spectrometry · 2024
    Article
  12. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jakub UjmaWaters Corporation, Wilmslow, SK9 4AX, United Kingdom.ORCID 0000-0002-2751-7750
Kevin GilesWaters Corporation, Wilmslow, SK9 4AX, United Kingdom.ORCID 0000-0001-5693-1064

Funding

Waters Select Series Cyclic IMS for P41 Native MS Resource Application to Alzheimer's DiseaseP41GM128577 · NIGMS · OHIO STATE UNIVERSITY · PI SOMOGYI, ARPAD · 2018 to 2022
$7.6M
Development of Surface-Induced Dissociation Ion Mobility MS, a Structrl Biol ToolR01GM113658 · NIGMS · OHIO STATE UNIVERSITY · PI WYSOCKI, VICKI H. · 2015 to 2018
$1.1M
NIGMS NIH HHS P41 GM128577NIGMS NIH HHS R01 GM113658
6 · The paper itself

Abstract

The use of charge-reducing reagents to generate lower-charge ions has gained popularity in the field of native mass spectrometry (MS) and ion mobility mass spectrometry (IM-MS). This is because the lower number of charged sites decreases the propensity for Coulombic repulsions and unfolding/restructuring, helping to preserve the native-like structure. Furthermore, lowering the charge state consequently increases the mass-to-charge values (

Indexed as

Databases, ProteinCalibrationIonsMass SpectrometryProteinsIonsProteins

Identifiers

PMID32048834
PMCPMC7170229

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.