Evidence map›Paper›PMID 32048804›Full record

Trial reportInternational journal of laboratory hematology2020

Hemoglobins F, A

Benchawan Kingchaiyaphum, Kanokwan Sanchaisuriya, Goonnapa Fucharoen, Attawut Chaibunruang, Sonja Y Hess, Guy-Marino Hinnouho, Maxwell A Barffour, Kimbery R Wessells, Sengchanh Kounnavong, Supan Fucharoen

Registry-linked trialOpen access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of laboratory hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02428647 (Lao Zinc Study), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02428647 nacompletednot on this map

Lao Zinc Study: The Effects of Two Forms of Daily Preventive Zinc Supplementation Versus Therapeutic Zinc Supplementation for Diarrhea on Young Children's Physical Growth and Risk of New Episodes of Diarrhea

TypeinterventionalSponsorUniversity of California, DavisRan2015 to 2017Enrolled3,433ConditionsDiarrheaArmsMNP, preventive zinc supplement, therapeutic zinc supplement, preventive placebo supplement, therapeutic placebo supplement
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Hemoglobins F, AInternational journal of laboratory hematology · 2020
    Trial
  4. Update in Laboratory Diagnosis of Thalassemia.Frontiers in molecular biosciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Benchawan KingchaiyaphumGraduate School, Khon Kaen University, Khon Kaen, Thailand.
Kanokwan SanchaisuriyaCenter for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0001-7453-9218
Goonnapa FucharoenCenter for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Attawut ChaibunruangCenter for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Sonja Y HessInstitute for Global Nutrition, University of California, Davis, CA, USA.
Guy-Marino HinnouhoInstitute for Global Nutrition, University of California, Davis, CA, USA.
Maxwell A BarffourInstitute for Global Nutrition, University of California, Davis, CA, USA.
Kimbery R WessellsInstitute for Global Nutrition, University of California, Davis, CA, USA.
Sengchanh KounnavongLao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao.
Supan FucharoenCenter for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.ORCID https://orcid.org/0000-0001-9142-5079
Khon Kaen University · THUniversity of California, Davis · USMinistry of Health · LA

Funding

Bill and Melinda Gates FoundationMathile Institute for the Advancement of Human Nutrition, Nutrition International
6 · The paper itself

Abstract

introductionDetermination of hemoglobins (Hbs) F, A

methodsA total of 698 blood samples of Laotian children including 272 non-Hb E, 271 Hb E heterozygotes, and 155 Hb E homozygotes were collected. Hb profiles were determined using the capillary zone electrophoresis. Coinheritance of α-thalassemia and the homozygosity for Hb E mutation were checked by PCR-based assay.

resultsChildren heterozygous and homozygous for Hb E had significantly higher Hb F and A

conclusionsOur findings can guide the development of a diagnostic approach to thalassemia in children aged 6-23 months.

Indexed as

alpha-ThalassemiaFetal HemoglobinHemoglobin A2Hemoglobin EHeterozygoteHomozygoteAge FactorsFemaleHumansInfantLaosMaleSex FactorsFetal HemoglobinHemoglobin A2Hemoglobin Ehemoglobin A2hemoglobin Ehemoglobin Fhemoglobinopathythalassemiayoung children

Identifiers

PMID32048804
PMCPMC7318314
OpenAlexW3006607504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.