ArticleNeuro-oncology2020
Consensus recommendations for a standardized brain tumor imaging protocol for clinical trials in brain metastases.
Article in Neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 3 of them syntheses that pooled it.
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Who cites it
160 citing papers in PubMed, 3 syntheses or guidelines pooled it, 247 citations in OpenAlex.
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- Brain metastases: A Society for Neuro-Oncology (SNO) consensus review on current management and future directions.Neuro-oncology · 2022Guideline
- Interim FDG-PET improves treatment failure prediction in primary central nervous system lymphoma: An LOC network prospective multicentric study.Neuro-oncology · 2024Trial
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- Artificial intelligence-amplified contrast enhancement in brain magnetic resonance imaging for improving image quality and lesion visualization: a prospective pilot study.Quantitative imaging in medicine and surgery · 2026Article
- BrainGAN Framework for Generating Synthetic Contrast-Enhanced Multisequence MRI in Brain Metastases.Journal of imaging informatics in medicine · 2026Article
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- A Framework for MRI Characterization of Intracranial Metastatic Disease.Radiology. Imaging cancer · 2026Review
- Report-Level Impact of DL Assistance on Teleradiology Quality Support for Brain Metastases: Real-World Clinical Practice at a Single Tertiary Center.Diagnostics (Basel, Switzerland) · 2026Article
- Hybrid CNN-GCN framework for brain tumor MRI classification: A graph-based approach to smart healthcare diagnostics.Journal of applied clinical medical physics · 2026Article
- Improving small brain metastasis detection with composite and augmented TQuantitative imaging in medicine and surgery · 2026Article
- Identifying Prognostic Factors in Brain Metastasis Patients Using MRI Morphological Features: A Machine Learning and Survival Analysis Approach.Diagnostics (Basel, Switzerland) · 2026Article
- A Challenging Differential Diagnosis Between Brain Radionecrosis and Recurrent Metastatic Disease, with Temporary Clinical/Radiological Response to Bevacizumab and Later Imaging Suspicious for Oligoprogression.Life (Basel, Switzerland) · 2026Article
- Development of head-to-head and longitudinal CycleGAN algorithm for MRI harmonization: validation in follow-up MRI evaluation in patients with brain metastasis.Scientific reports · 2026Article
- Technical Development and Implementation of 3D-QALAS on a 1.5T MR-Linac for the Brain: A Prospective R-IDEAL Stage 0/1 Technology Development Report.medRxiv : the preprint server for health sciences · 2026Article
- GPT-4 for automated sequence-level determination of MRI protocols based on radiology request forms from clinical routine.European radiology · 2026Article
- Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1.Cell reports · 2026Article
100 more citing papers are in PubMed but not listed here.
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20 authors at 14 institutions in 3 countries.
Funding
Abstract
A recent meeting was held on March 22, 2019, among the FDA, clinical scientists, pharmaceutical and biotech companies, clinical trials cooperative groups, and patient advocacy groups to discuss challenges and potential solutions for increasing development of therapeutics for central nervous system metastases. A key issue identified at this meeting was the need for consistent tumor measurement for reliable tumor response assessment, including the first step of standardized image acquisition with an MRI protocol that could be implemented in multicenter studies aimed at testing new therapeutics. This document builds upon previous consensus recommendations for a standardized brain tumor imaging protocol (BTIP) in high-grade gliomas and defines a protocol for brain metastases (BTIP-BM) that addresses unique challenges associated with assessment of CNS metastases. The "minimum standard" recommended pulse sequences include: (i) parameter matched pre- and post-contrast inversion recovery (IR)-prepared, isotropic 3D T1-weighted gradient echo (IR-GRE); (ii) axial 2D T2-weighted turbo spin echo acquired after injection of gadolinium-based contrast agent and before post-contrast 3D T1-weighted images; (iii) axial 2D or 3D T2-weighted fluid attenuated inversion recovery; (iv) axial 2D, 3-directional diffusion-weighted images; and (v) post-contrast 2D T1-weighted spin echo images for increased lesion conspicuity. Recommended sequence parameters are provided for both 1.5T and 3T MR systems. An "ideal" protocol is also provided, which replaces IR-GRE with 3D TSE T1-weighted imaging pre- and post-gadolinium, and is best performed at 3T, for which dynamic susceptibility contrast perfusion is included. Recommended perfusion parameters are given.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.