ArticleOrganic & biomolecular chemistry2020
Chemical synthesis of human milk oligosaccharides: lacto-N-neohexaose (Galβ1 → 4GlcNAcβ1→)
Article in Organic & biomolecular chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Chemical Synthesis of Human Milk Oligosaccharides: Sialyllacto-The Journal of organic chemistry · 2025Article
- p-nitrobenzyloxycarbonyl protective group as key to automated glycan assembly of neutral human milk oligosaccharides.Nature communications · 2025Article
- Chemical Synthesis of Two Fucosylated Human Milk Oligosaccharides: 3-Fucosyllactose and Lacto-N-fucopentaose V.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Glycosyltransferases: glycoengineers in human milk oligosaccharide synthesis and manufacturing.Frontiers in molecular biosciences · 2025Review
- Recent advances in the science of human milk oligosaccharides.BBA advances · 2025Article
- Article
- Synthesis of 2-Amino-2-deoxy Sugars via Boron-Catalyzed Coupling of Glycosyl Fluorides and Silyl Ether Acceptors.Organic letters · 2024Article
- Chemical Synthesis of Human Milk Oligosaccharides: para-Lacto-N-hexaose and para-Lacto-N-neohexaose.Chemistry (Weinheim an der Bergstrasse, Germany) · 2023Article
- Prebiotics in New-Born and Children's Health.Microorganisms · 2023Review
- Substrate and Process Engineering for Biocatalytic Synthesis and Facile Purification of Human Milk Oligosaccharides.ChemSusChem · 2022Article
- Chemoenzymatic Synthesis of Asymmetrically Branched Human Milk Oligosaccharide Lacto-Frontiers in chemistry · 2022Article
- Synthesis as an Expanding Resource in Human Milk Science.Journal of the American Chemical Society · 2021Review
- Microbial production of human milk oligosaccharide lactodifucotetraose.Metabolic engineering · 2021Article
- Like mother, like microbe: human milk oligosaccharide mediated microbiome symbiosis.Biochemical Society transactions · 2020Review
- The Impact of Dietary Fucosylated Oligosaccharides and Glycoproteins of Human Milk on Infant Well-Being.Nutrients · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The first chemical synthesis of lacto-N-neohexaose (LNnH) has been completed using a convergent synthetic strategy. The reaction conditions and donor-acceptor combinations have been carefully refined to minimize side reactions and achieve high yields in all glycosylation steps. Lacto-N-neotetraose, another common human milk oligosaccharide, was also synthesized en route to the target LNnH.
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Registered trials
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