Evidence map›Paper›PMID 32048154›Full record

ArticleObesity surgery2020

Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery.

Thomas Mouillot, Nybel Rhyman, Cyril Gauthier, Justine Paris, Anne-Sophie Lang, Sarah Lepers-Tassy, Sylvain Manfredi, Côme Lepage, Corinne Leloup, Agnès Jacquin-Piques and 2 more

Abstract read
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In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Observational
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Breath Tests Used in the Context of Bariatric Surgery.Diagnostics (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Article
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  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Thomas MouillotCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France. thomas.mouillot@chu-dijon.fr.ORCID http://orcid.org/0000-0002-0767-3035
Nybel RhymanService d'hépato-gastro-entérologie, CHU F. Mitterrand, F-21000, Dijon, France.
Cyril GauthierEspace Médical Nutrition et Obésité, Ramsay Santé, 4 rue Lounes Matoub, F-21000, Dijon, France.
Justine ParisService de Pharmacie, CHU F. Mitterrand, F-21000, Dijon, France.
Anne-Sophie LangService de Pharmacie, CHU F. Mitterrand, F-21000, Dijon, France.
Sarah Lepers-TassyCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France.
Sylvain ManfrediService d'hépato-gastro-entérologie, CHU F. Mitterrand, F-21000, Dijon, France.
Côme LepageService d'hépato-gastro-entérologie, CHU F. Mitterrand, F-21000, Dijon, France.
Corinne LeloupCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France.
Agnès Jacquin-PiquesCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France.
Marie-Claude BrindisiCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France.
Laurent BrondelCentre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSmall intestinal bacterial overgrowth (SIBO) is a common complication of bariatric surgery. Digestive decontamination treatments with oral antibiotic therapy vary and are not codified. This retrospective study was conducted to analyse the characteristics of bariatric surgery patients who underwent a glucose breath test (GBT) and to analyse the effectiveness of the antibiotic decontamination therapy. MATERIALS AND

methodsA total of 101 operated patients (Roux-en-Y bypass (RYB), omega bypass (ΩB) and sleeve gastrectomy (SG)) who underwent a GBT (75 g/250 mL) were included. Anthropometric data, symptoms of SIBO, type of surgery, use of proton pump inhibitors (PPIs) and antibiotic therapy were analysed. The effectiveness of the antibiotic treatment, defined by improvement of the symptoms, was evaluated during the follow-up.

resultsOf the 85 women and 16 men included (48.5 ± 3.6 years old), 63 underwent RYB, 31 underwent ΩB and 7 underwent SG. The GBT was positive in 83% of the patients. A positive test was associated with age (p < 0.001), female sex (p < 0.01) and PPI use (p < 0.01), but there was no significant difference according to the type of surgery. Sixty-one percent of patients treated with gentamicin/metronidazole sequential antibiotic therapy and 58% of patients treated with metronidazole alone achieved treatment efficacy (with no significant difference in efficacy between these treatments).

conclusionSIBO should be systematically considered in the context of abdominal symptoms in bariatric surgery patients, regardless the type of surgery, particularly in patients who are older or female and after PPI treatment. Digestive decontamination appears to be similar between gentamycin/metronidazole and metronidazole treatments.

Indexed as

Bariatric SurgeryObesity, MorbidAdultAnti-Bacterial AgentsFemaleGastrectomyHumansMaleMiddle AgedRetrospective StudiesAnti-Bacterial AgentsAntibiotic therapyBariatric surgeryGlucose breath testObesitySmall intestinal bacterial overgrowth (SIBO)

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.