ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2020
Effect of postoperative hypoalbuminemia and supplement of human serum albumin on the development of surgical site infection following spinal fusion surgery: a retrospective study.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 31 citations in OpenAlex.
- Appropriateness of perioperative albumin administration in gastrointestinal tumor surgery patients without hypoalbuminemia: a propensity score-matched study.International journal of clinical pharmacy · 2026Article
- Incidence and Independent Risk Factors of Spinal Infection After Vertebral Augmentation: A Multicenter Propensity-Matched Case-Control Study.Neurospine · 2026Article
- The prognostic nutritional index is an early predictive marker for surgical site infection after spinal fusion surgery: a nested case-control study.BMC surgery · 2026Article
- The clinical application of parenteral nutrition with Omega-3 fatty acids in patients after gastrectomy: a retrospective cohort study and cost-effectiveness analysis.Lipids in health and disease · 2026Article
- Interpretable machine learning model for predicting postoperative hypoproteinemia in middle-aged and elderly patients following total joint arthroplasty: a multicenter retrospective study.Frontiers in nutrition · 2026Article
- Prognostic nutritional index versus pragmatically operationalized GLIM criteria for predicting postoperative complications and recovery in spine surgery: a prospective cohort study.Frontiers in nutrition · 2026Article
- Establishment and validation of a nomogram model for surgical site infections after posterior lumbar interbody fusion: a retrospective observational study.Neurosurgical review · 2025Observational
- Surgical site infection rate in spine surgery, incidence, and risk factors: a ten-year retrospective cohort review in a developing neurosurgical centre.BMC surgery · 2025Article
- Risk Factors of Surgical Site Infection After Adult Closed Tibial Plateau Fractures Treated by Open Reduction and Internal Fixation.Infection and drug resistance · 2025Article
- Cerebrospinal Fluid Leakage Combined with Blood Biomarkers Predicts Poor Wound Healing After Posterior Lumbar Spinal Fusion: A Machine Learning Analysis.International journal of general medicine · 2024Article
- Article
- Risk factors for incisional complications after lumbar internal fixation via posterior midline approach: A case-control study of 455 consecutive cases.International wound journal · 2023Article
- Establishment of a prediction model of postoperative infection complications in patients with gastric cancer and its impact on prognosis.Journal of gastrointestinal oncology · 2023Article
- Association between immediate postoperative hypoalbuminemia and surgical site infection after posterior lumbar fusion surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2023Article
- Association between 20% Albumin Use and Acute Kidney Injury in Major Abdominal Surgery with Transfusion.International journal of molecular sciences · 2023Article
- Prognostic nomogram for predicting lower extremity deep venous thrombosis in ruptured intracranial aneurysm patients who underwent endovascular treatment.Frontiers in neurology · 2023Article
- The risk factors of the postoperative poor wound healing in spinal tuberculosis patients: A single centre retrospective cohort study.International wound journal · 2022Article
- Value of Postoperative Serum Albumin to Predict Postoperative Complication Severity in Spinal Tuberculosis.BioMed research international · 2022Article
- Association between hypoalbuminemia and complications after degenerative and deformity-correcting spinal surgeries: A systematic review and meta-analysis.Frontiers in surgery · 2022Review
- What Level Should Preoperative Albumin of Thoracic and Lumbar Tuberculosis Patients Be Reached: A Case-Controlled Study.Frontiers in nutrition · 2022Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the association between postoperative hypoalbuminemia and the development of surgical site infection (SSI) and evaluate whether the supplement of exogenous human serum albumin (HSA) in patients following spinal surgery would decrease the rate of postoperative SSI.
methodsWe performed a retrospective review of all patients who underwent lumbar spinal fusion surgery in our institution between January 2014 and December 2018. Patients with postoperative SSI were identified. We reviewed the demographic and clinical records of the patients and performed multiple logistic regression models to clarify the relevance between postoperative hypoalbuminemia, the supplement of HSA and SSI. Statistical adjustment for the potential confounders was also performed to exclude possible variation.
resultsTwenty-four of 602 patients developed SSI after lumbar spinal fusion surgery. No statistical significance was found between postoperative hypoalbuminemia and SSI rate (OR 0.74; 95% CI 0.22-2.48; P = 0.6199). However, the supplement of exogenous HSA was significantly associated with increased postoperative SSI rate (OR 1.21; 95% CI 1.05-1.41; P = 0.0094). Interestingly, stratified analyses showed supplement of HSA in patients without postoperative hypoalbuminemia increased the risk of SSI (OR 2.55; 95% CI 1.01-6.45; P = 0.0475), compared with patients with postoperative hypoalbuminemia (OR 1.17; 95% CI 1.00-1.36; P = 0.0434).
conclusionsThe present study suggests that postoperative hypoalbuminemia is not associated with the development of SSI after spinal surgery. However, the supplement of HSA following spinal surgery will increase the rate of SSI. These slides can be retrieved under Electronic Supplementary Material.
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