ArticleSchizophrenia bulletin2020
Threatening Life Events and Difficulties and Psychotic Disorder.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Feeling out of place: a qualitative study on pathways from social adversities to early psychosis.Social psychiatry and psychiatric epidemiology · 2026Article
- Stressful life events and their association with symptom severity and functioning in first-episode psychosis.Schizophrenia (Heidelberg, Germany) · 2026Article
- Childhood Adversities and Psychosis Across Populations: Insights From the 6-Country EU-GEI Study.Schizophrenia bulletin · 2026Article
- Multimodal prediction of psychotic-like experiences using elastic net modeling: external validation in a clinical sample.Psychological medicine · 2025Article
- Immersive virtual reality as a novel approach to investigate the association between adverse events and adolescent paranoid ideation.Social psychiatry and psychiatric epidemiology · 2025Article
- The Interaction of Polygenic Susceptibility to Stress and Childhood Adversity Dimensions Predicts Longitudinal Trajectories of Stress-Sensitivity.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Stress, Environment and Early Psychosis.Current neuropharmacology · 2024Review
- Association between stressful life events and depression, anxiety, and quality of life among urban adolescents and young adults in Latin America.Frontiers in psychology · 2024Article
- "Association between Traumatic Life Events and Psychosis: A case-control study in western Kenya".Heliyon · 2023Article
- Effect of Cytomegalovirus on the Immune System: Implications for Aging and Mental Health.Current topics in behavioral neurosciences · 2023Article
- Negative life events and stress sensitivity in youth's daily life: an ecological momentary assessment study.Social psychiatry and psychiatric epidemiology · 2022Article
- The Association Between Life Events and Incidence of Hypertension Among Government Employees in China: A Prospective Cohort Study.Frontiers in psychology · 2022Article
- Hippocampal regenerative medicine: neurogenic implications for addiction and mental disorders.Experimental & molecular medicine · 2021Review
- General psychopathology links burden of recent life events and psychotic symptoms in a network approach.NPJ schizophrenia · 2020Article
- Threat, hostility and violence in childhood and later psychotic disorder: population-based case-control study.The British journal of psychiatry : the journal of mental science · 2020Article
- Interpersonal Violence and Psychotic-Like Experiences: The Mediation of Ideas of Reference, Childhood Memories, and Dissociation.International journal of environmental research and public health · 2020Article
- A comparison between self-report and interviewer-rated retrospective reports of childhood abuse among individuals with first-episode psychosis and population-based controls.Journal of psychiatric research · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
objectiveStressful life events have been implicated in the onset of psychotic disorders, but there are few robust studies. We sought to examine the nature and magnitude of associations between adult life events and difficulties and first-episode psychoses, particularly focusing on contextual characteristics, including threat, intrusiveness, and independence.
methodThis study forms part of the Childhood Adversity and Psychosis Study (CAPsy), an epidemiological case-control study in London, United Kingdom. Data on life events and difficulties (problems lasting 4 wk or more) during 1 year prior to onset (cases) or interview (controls) were assessed using the semi-structured Life Events and Difficulties Schedule (LEDS). Data were available on 253 individuals with a first episode of psychosis and 301 population-based controls.
resultsWe found strong evidence that odds of exposure to threatening and intrusive events in the 1 year prior to onset were substantially higher among cases compared with controls, independent of age, gender, ethnicity, and social class (ORs > 3). This was consistent across diagnostic categories. We found further evidence that the effect of threatening events and difficulties was cumulative (1 event odds ratio [OR] 2.69 [95% confidence interval (CI) 1.51-4.79]; 2 events OR 4.87 [95% CI 2.34-10.16]; ≥3 events OR 5.27 [95% CI 1.83-15.19]; 1 difficulty OR 3.02 [95% CI 1.79-5.09]; 2 difficulties OR 9.71 [95% CI 4.20-22.40]; ≥3 difficulties OR 12.84 [95% CI 3.18-51.85]).
conclusionsThreatening and intrusive life events and difficulties are common in the year pre-onset among individuals with a first episode of psychosis. Such experiences may contribute to the development of psychotic disorders.
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