ArticleSchizophrenia bulletin2020
Opposing Changes in the Functional Architecture of Large-Scale Networks in Bipolar Mania and Depression.
Article in Schizophrenia bulletin, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- A working model linking the psychopathology and pathophysiology of major depressive disorder - an umbrella review of neuroimaging studies and a conceptual framework.Molecular psychiatry · 2025Pooled it
- Biological correlates of temperament: systematic reviews, empirical studies, and a conceptual framework linking neurotransmitter signaling, intrinsic brain activity, and the hyperthymic-depressive spectrum.Molecular psychiatry · 2025Pooled it
- Altered spontaneous brain activity in patients with diabetic optic neuropathy: A resting-state functional magnetic resonance imaging study using regional homogeneity.World journal of diabetes · 2021Trial
- Polarisation of brain dynamics in mania and depression.Dialogues in clinical neuroscience · 2026Article
- [Dynamic alterations in regional brain activity associated with bipolar disorder and smoking status].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Article
- Disorganisation and depression: a re-examination of how we think and speak when depressed.European archives of psychiatry and clinical neuroscience · 2026Review
- Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study.BMC medicine · 2025Article
- Common and disease-specific patterns of functional connectivity and topology alterations across unipolar and bipolar disorder during depressive episodes: a transdiagnostic study.Translational psychiatry · 2025Article
- Multimodal MRI study of gray matter and functional connectivity abnormalities in adolescents with bipolar disorder.Frontiers in psychiatry · 2025Article
- Aberrant resting-state functional network centrality and cognitive impairment in unmedicated, euthymic bipolar patients.BMC psychiatry · 2024Article
- Disrupted default mode network connectivity in bipolar disorder: a resting-state fMRI study.BMC psychiatry · 2024Article
- Effects of mini-basketball training program on social communication impairments and regional homogeneity of brain functions in preschool children with autism spectrum disorder.BMC sports science, medicine & rehabilitation · 2024Article
- Motor performance and functional connectivity between the posterior cingulate cortex and supplementary motor cortex in bipolar and unipolar depression.European archives of psychiatry and clinical neuroscience · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Abnormal characteristic static and dynamic functional network connectivity in idiopathic normal pressure hydrocephalus.CNS neuroscience & therapeutics · 2024Article
- Decreased dynamic variability of the cerebellum in the euthymic patients with bipolar disorder.BMC psychiatry · 2024Article
- Impaired mitochondrial function in bipolar disorder and alcohol use disorder: a case study usingPsychoradiology · 2024Article
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states.General psychiatry · 2024Review
- Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder.BMC psychiatry · 2023Article
- Seasonal effect-an overlooked factor in neuroimaging research.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveManic and depressive phases of bipolar disorder (BD) show opposite symptoms in psychomotor, thought, and affective dimensions. Neuronally, these may depend on distinct patterns of alterations in the functional architecture of brain intrinsic activity. Therefore, the study aimed to characterize the spatial and temporal changes of resting-state activity in mania and depression, by investigating the regional homogeneity (ReHo) and degree of centrality (DC), in different frequency bands.
methodsUsing resting-state functional magnetic resonance imaging (fMRI), voxel-wise ReHo and DC were calculated-in the standard frequency band (SFB: 0.01-0.10 Hz), as well as in Slow5 (0.01-0.027 Hz) and Slow4 (0.027-0.073 Hz)-and compared between manic (n = 36), depressed (n = 43), euthymic (n = 29) patients, and healthy controls (n = 112). Finally, clinical correlations were investigated.
resultsMania was mainly characterized by decreased ReHo and DC in Slow4 in the medial prefrontal cortex (as part of the default-mode network [DMN]), which in turn correlated with manic symptomatology. Conversely, depression was mainly characterized by decreased ReHo in SFB in the primary sensory-motor cortex (as part of the sensorimotor network [SMN]), which in turn correlated with depressive symptomatology.
conclusionsOur data show a functional reconfiguration of the spatiotemporal structure of intrinsic brain activity to occur in BD. Mania might be characterized by a predominance of sensorimotor over associative networks, possibly driven by a deficit of the DMN (reflecting in internal thought deficit). Conversely, depression might be characterized by a predominance of associative over sensorimotor networks, possibly driven by a deficit of the SMN (reflecting in psychomotor inhibition).
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