Evidence map›Paper›PMID 32047884›Full record

ArticleEuropean heart journal2020

Physical activity, cardiorespiratory fitness, and cardiovascular outcomes in individuals with atrial fibrillation: the HUNT study.

Lars E Garnvik, Vegard Malmo, Imre Janszky, Hanne Ellekjær, Ulrik Wisløff, Jan P Loennechen, Bjarne M Nes

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06114095 (Single Cell Sequencing and Multidimensional Omics Studies in Cardiovascular and Neurological Diseases), which is not on this map. Cited by 49 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 3 pooled it
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06114095 unknown statusnot on this mapstarted 2023, after this paper: background citation

Single Cell Sequencing and Multidimensional Omics Studies in Cardiovascular and Neurological Diseases

TypeobservationalSponsorTao XinRan2023 to 2026Enrolled400ConditionsNervous System Diseases, Cardiovascular Diseases
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 3 syntheses or guidelines pooled it, 103 citations in OpenAlex.

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  6. Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Review
  7. Physical activity and risk of adverse events in atrial fibrillation: evidence from European and Asian cohorts.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Lars E GarnvikDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter, PO Box 8905, 7491 Trondheim, Norway.
Vegard MalmoDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter, PO Box 8905, 7491 Trondheim, Norway.
Imre JanszkyDepartment of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter, PO Box 8905, 7491 Trondheim, Norway.
Hanne EllekjærStroke Unit, Department of Internal Medicine, St Olav's Hospital, Harald Hardrådes gate 14, 7030 Trondheim, Norway.
Ulrik WisløffDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter, PO Box 8905, 7491 Trondheim, Norway.
Jan P LoennechenDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter, PO Box 8905, 7491 Trondheim, Norway.
Bjarne M NesDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Medisinsk Teknisk Forskningssenter, PO Box 8905, 7491 Trondheim, Norway.
Norwegian University of Science and Technology · NOSemmelweis University · HUThe University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsAtrial fibrillation (AF) confers higher risk of mortality and morbidity, but the long-term impact of physical activity (PA) and cardiorespiratory fitness (CRF) on outcomes in AF patients is unknown. We, therefore, examined the prospective associations of PA and estimated CRF (eCRF) with all-cause mortality, cardiovascular disease (CVD) mortality, morbidity and stroke in individuals with AF. METHODS AND

resultsWe followed 1117 AF patients from the HUNT3 study in 2006-08 until first occurrence of the outcomes or end of follow-up in November 2015. We used Cox proportional hazard regression to examine the prospective associations of self-reported PA and eCRF with the outcomes. Atrial fibrillation patients meeting PA guidelines had lower risk of all-cause [hazard ratio (HR) 0.55, 95% confidence interval (CI) 0.41-0.75] and CVD mortality (HR 0.54, 95% CI 0.34-0.86) compared with inactive patients. The respective HRs for CVD morbidity and stroke were 0.78 (95% CI 0.58-1.04) and 0.70 (95% CI 0.42-1.15). Each 1-metabolic equivalent task (MET) higher eCRF was associated with a lower risk of all-cause (HR 0.88, 95% CI 0.81-0.95), CVD mortality (HR 0.85, 95% CI 0.76-0.95), and morbidity (HR 0.88, 95% CI 0.82-0.95).

conclusionHigher PA and CRF are associated with lower long-term risk of CVD and all-cause mortality in individuals with AF. The findings support a role for regular PA and improved CRF in AF patients, in order to combat the elevated risk for mortality and morbidity.

Indexed as

Atrial FibrillationCardiorespiratory FitnessCardiovascular DiseasesExerciseHumansPhysical FitnessProspective StudiesRisk FactorsArrhythmiasCardiovascular diseaseExercisePopulation

Identifiers

PMID32047884
PMCPMC7320825
OpenAlexW3006249023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.