Evidence map›Paper›PMID 32047777›Full record

ArticleWorld journal of clinical cases2020

LINX

Dimitrios Schizas, Aikaterini Mastoraki, Eleni Papoutsi, Vassilis G Giannakoulis, Prodromos Kanavidis, Diamantis Tsilimigras, Dimitrios Ntourakis, Orestis Lyros, Theodore Liakakos, Dimitrios Moris

Registry-linked trialOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05238636 (The Effect of Anti-reflux Procedures), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05238636 unknown statusnot on this mapstarted 2022, after this paper: background citation

The Effect of Anti-reflux Procedures (Stretta, LINX, and Fundoplication) on Physiological Parameters Contributing to Symptom Resolution in Adults With Gastro-oesophageal Reflux at a Single UK Tertiary Centre

TypeobservationalSponsorSt George's, University of LondonRan2022 to 2024Enrolled60ConditionsGastroesophageal RefluxArmsAnti-reflux surgery - Stretta procedure or LINX device or laparoscopic fundoplication
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Magnetic challenge against gastroesophageal reflux.World journal of gastroenterology · 2021
    Review
  6. Practice-Changing Milestones in Anti-reflux and Hiatal Hernia Surgery: a Single Surgeon Perspective over 27 years and 1200 Operations.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Dimitrios Schizas1 Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens 11527, Greece.
Aikaterini Mastoraki4 Department of Surgery, National and Kapodistrian University of Athens, Attikon University Hospital, Chaidari, Athens 11527, Greece.
Eleni Papoutsi1 Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens 11527, Greece.
Vassilis G Giannakoulis1 Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens 11527, Greece.
Prodromos Kanavidis1 Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens 11527, Greece.
Diamantis TsilimigrasDepartment of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Cancer Hospital and Solove Research Institute, Columbus, OH 45830, United States.
Dimitrios NtourakisDepartment of Surgery, School of Medicine, European University Cyprus, Nicosia 2404, Cyprus.
Orestis LyrosDepartment of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, Leipzig 04103, Germany.
Theodore Liakakos1 Department of Surgery, National and Kapodistrian University of Athens, Laikon Hospital, Athens 11527, Greece.
Dimitrios MorisDepartment of Surgery, Duke University Medical Center, Duke University, Durham, NC 27705, United States. dimmoris@yahoo.com.
Duke Medical Center · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastroesophageal reflux disease (GERD) occurs when the reflux of stomach contents causes troublesome symptoms and/or complications. When medical therapy is insufficient, surgical therapy is indicated and, until now, Laparoscopic fundoplication (LF) constitutes the gold-standard method. However, magnetic sphincter augmentation (MSA) using the LINX

aimTo investigate the device's safety and efficacy in resolving GERD symptoms.

methodsThis is a systematic review conducted in accordance to the PRISMA guidelines. We searched MEDLINE, Clinicaltrials.gov, EMBASE, Cochrane Central Register of Controlled Trials CENTRAL databases from inception until September 2019.

resultsOverall, 35 studies with a total number of 2511 MSA patients were included and analyzed. Post-operative proton-pump inhibitor (PPI) cessation rates reached 100%, with less bloating symptoms and a better ability to belch or vomit in comparison to LF. Special patient groups (

conclusionThe findings of our review suggest that MSA has the potential to bridge the treatment gap between maxed-out medical treatment and LF. However, further studies with longer follow-up are needed for a better elucidation of these results.

Indexed as

Gastroesophageal reflux diseaseGastroesophageal reflux disease - health - related quality of lifeLINX® reflux management systemMagnetic sphincter augmentation

Identifiers

PMID32047777
PMCPMC7000944
OpenAlexW2999613350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.