Evidence map›Paper›PMID 32047643›Full record

SynthesisGlobal health, epidemiology and genomics2019

The role of epigenetics in respiratory health in urban populations in low and middle-income countries.

Nicole M Robertson, Alex Kayongo, Trishul Siddharthan, Suzanne L Pollard, Jose Gomez Villalobos, Christine Ladd-Acosta, Bruce Kirenga, William Checkley

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Global health, epidemiology and genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Nicole M RobertsonDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore,MD, USA.ORCID 0000-0003-2139-8321
Alex KayongoDepartment of Immunology and Molecular Biology, Makerere University College of Health Sciences, Kampala, Uganda.
Trishul SiddharthanDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore,MD, USA.
Suzanne L PollardDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore,MD, USA.
Jose Gomez VillalobosDivision of Pulmonary and Critical Care, Yale University, New Haven,CT, USA.
Christine Ladd-AcostaDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore,MD, USA.
Bruce KirengaDivision of Pulmonary Medicine, Makerere University Lung Institute, Mulago Hospital, Makerere University, Kampala, Uganda.
William CheckleyDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore,MD, USA.
Johns Hopkins University · USMakerere University · UGMulago Hospital · UGYale University · US

Funding

Effectiveness of Low-dose Theophylline for the Management of Biomass-associated COPD in PeruK23HL146946 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SIDDHARTHAN, TRISHUL · 2019 to 2023
$985k
NHLBI NIH HHS K23 HL146946
6 · The paper itself

Abstract

As urbanization increases in low- and middle-income countries (LMICs), urban populations will be increasingly exposed to a range of environmental risk factors for non-communicable diseases. Inadequate living conditions in urban settings may influence mechanisms that regulate gene expression, leading to the development of non-communicable respiratory diseases. We conducted a systematic review of the literature to assess the relationship between respiratory health and epigenetic factors to urban environmental exposures observed in LMICs using MEDLINE, PubMed, EMBASE, and Google Scholar searching a combination of the terms: epigenetics, chronic respiratory diseases (CRDs), lung development, chronic obstructive airway disease, and asthma. A total of 2835 articles were obtained, and 48 articles were included in this review. We found that environmental factors during early development are related to epigenetic effects that may be associated with a higher risk of CRDs. Epigenetic dysregulation of gene expression of the histone deacetylase (HDAC) and histone acetyltransferase gene families was likely involved in lung health of slum dwellers. Respiratory-related environmental exposures influence HDAC function and deoxyribonucleic acid methylation and are important risk factors in the development of CRD. Additional epigenetic research is needed to improve our understanding of associations between environmental exposures and non-communicable respiratory diseases.

Indexed as

Epigenesis, GeneticUrban PopulationAsthmaDeveloping CountriesEnvironmental ExposureHumansLungPoverty AreasPulmonary Disease, Chronic ObstructiveChronic respiratory diseasesepigeneticslow and middle-income countriesslum dwellers

Identifiers

PMID32047643
PMCPMC6983949
OpenAlexW2991394673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.