Evidence map›Paper›PMID 32047610›Full record

ReviewF1000Research2020

Blood making: learning what to put into the dish.

Ana G Freire, Jason M Butler

Abstract readReview
In one paragraph

Review in F1000Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Zebrafish models of acute leukemias: Current models and future directions.Wiley interdisciplinary reviews. Developmental biology · 2021
    Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ana G FreireCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, USA.
Jason M ButlerCenter for Discovery and Innovation, Hackensack University Medical Center, Nutley, USA.

Funding

Rejuvenation of aged hematopoietic stem cells and endothelial niches by thrombospondin-1 blockadeR01AG065436 · NIA · UNIVERSITY OF FLORIDA · PI BUTLER, JASON MATHEW · 2019 to 2023
$2.9M
Modulating signaling pathways in endothelial cells to abate leukemic progression.R01CA204308 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, JASON MATHEW · 2016 to 2020
$2.0M
Modulating endothelial-specific signaling to enhance functional hematopoiesis.R01HL133021 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI BUTLER, JASON MATHEW · 2016 to 2019
$1.7M
NCI NIH HHS R01 CA204308NHLBI NIH HHS R01 HL133021NIA NIH HHS R01 AG065436
6 · The paper itself

Abstract

The generation of hematopoietic stem cells (HSCs) from pluripotent stem cell (PSC) sources is a long-standing goal that will require a comprehensive understanding of the molecular and cellular factors that determine HSC fate during embryogenesis. A precise interplay between niche components, such as the vascular, mesenchymal, primitive myeloid cells, and the nervous system provides the unique signaling milieu for the emergence of functional HSCs in the aorta-gonad-mesonephros (AGM) region. Over the last several years, the interrogation of these aspects in the embryo model and in the PSC differentiation system has provided valuable knowledge that will continue educating the design of more efficient protocols to enable the differentiation of PSCs into

Indexed as

Stem Cell NicheAnimalsCell Culture TechniquesEmbryo, MammalianGonadsHematopoiesisHematopoietic Stem CellsHumansMesonephrosPluripotent Stem CellsAGMhematopoietic stem cellhemogenic endotheliumpluripotent stem cell

Identifiers

PMID32047610
PMCPMC6979482

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.