Evidence map›Paper›PMID 32047485›Full record

ArticleFrontiers in microbiology2019

CusS-CusR Two-Component System Mediates Tigecycline Resistance in Carbapenem-Resistant

Dongjie Chen, Yunan Zhao, Yanqin Qiu, Liying Xiao, Huaqiang He, Dongmei Zheng, Xiaoqin Li, Xiaoli Yu, Nengluan Xu, Xinlan Hu and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Phase-Specific Antibiotic Resistance Mechanisms in anbioRxiv : the preprint server for biology · 2025
    Article
  5. Review
  6. Insights into Kinases of ESKAPE Pathogens for Therapeutic Interventions.Cardiovascular & hematological agents in medicinal chemistry · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Anatomy of an extensively drug-resistantProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  13. Molecular characterization of carbapenem-resistantJournal of medical microbiology · 2021
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Dongjie ChenShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Yunan ZhaoShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Yanqin QiuShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Liying XiaoShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Huaqiang HeShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Dongmei ZhengShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Xiaoqin LiDepartment of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fuzhou, China.
Xiaoli YuDepartment of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fuzhou, China.
Nengluan XuDepartment of Pulmonary and Critical Care Medicine, Fujian Provincial Hospital, Fuzhou, China.
Xinlan HuClinical Microbiology Laboratory, Fujian Provincial Hospital, Fuzhou, China.
Falin ChenClinical Microbiology Laboratory, Fujian Provincial Hospital, Fuzhou, China.
Hongru LiShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Yusheng ChenShengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Fujian Medical University · CNFujian Provincial Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe increase in carbapenem-resistant

methodsFollowing the

resultsNine strains of KP were evaluated in our study. Strains

conclusionIn addition to its primary function in resistance to copper/silver, the CusS-CusR two-component system is associated with CRKP resistance to tigecycline.

Indexed as

carbapenem resistanceCusS-CusR two-component systemKlebsiella pneumoniaeRNA sequencingtigecycline resistance

Identifiers

PMID32047485
PMCPMC6997431
OpenAlexW3003433209

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.