ReviewFrontiers in psychiatry2019
Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress.
Review in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 81 citations in OpenAlex.
- Nocturnal Risk Assessment and Its Association With Anxiety Symptoms.Psychophysiology · 2026Trial
- Daily rhythms in fear extinction memory reflect structural and functional changes in a prefrontal-amygdala circuit.Brain structure & function · 2026Article
- Early Life Stress and Adversity in Children: Neuroendocrine Mechanisms, Epigenetic Regulation, and Lifespan Developmental Outcomes-A Narrative Review.Children (Basel, Switzerland) · 2026Review
- Circadian instability following mass trauma predicts PTSD risk.Translational psychiatry · 2026Article
- The Light-Eye-Brain Axis: Neurobiological Links Between Mood Disorders and Myopia-A Narrative Review.Ophthalmology and therapy · 2026Review
- Circadian rhythm disruption impairs time-dependent dentine regeneration and reprograms the late-stage dental proteome in a mouse pulp injury model.Frontiers in pharmacology · 2026Article
- Stress-Induced Disruption of Circadian and Neuroimmune Networks in Lacrimal Glands Drives Dry Eye Pathogenesis.Investigative ophthalmology & visual science · 2025Article
- Clock Gene Expression Modulation by Low- and High-Intensity Exercise Regimens in Aging Mice.International journal of molecular sciences · 2025Article
- Machine Learning Models to Identify Clinically Significant Anxiety in Short-Term Insomnia Using Accelerometers.Depression and anxiety · 2025Article
- Social disadvantage is associated with impaired increase in salivary diurnal melatonin amplitude throughout pregnancy.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Epigenetic modifications and transgenerational inheritance in women victims of violence (EWVV).Environmental epigenetics · 2025Review
- Why mindfulness matters in musculoskeletal therapies: a narrative review.Frontiers in psychology · 2025Review
- Non-invasive ventral cervical magnetoneurography as a proxy of in vivo lipopolysaccharide-induced inflammation.Communications biology · 2024Article
- Diurnal variation of cardiac autonomic activity in adolescent non-suicidal self-injury.European archives of psychiatry and clinical neuroscience · 2024Article
- Learning from circadian rhythm to transform cancer prevention, prognosis, and survivorship care.Trends in cancer · 2024Review
- Developmental Neuroendocrinology of Early-Life Stress: Impact on Child Development and Behavior.Current neuropharmacology · 2024Review
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Role of stress in the pathogenesis of cancer (Review).International journal of oncology · 2023Review
- The Impact of Chronic Stress on Behavior and Body Mass in New Animal Models.Brain sciences · 2023Article
- From childhood adversity to latent stress vulnerability in adulthood: the mediating roles of sleep disturbances and HPA axis dysfunction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dramatic fluctuations in energy demands by the rhythmic succession of night and day on our planet has prompted a geophysical evolutionary need for biological temporal organization across phylogeny. The intrinsic circadian timing system (CS) represents a highly conserved and sophisticated internal "clock," adjusted to the 24-h rotation period of the earth, enabling a nyctohemeral coordination of numerous physiologic processes, from gene expression to behavior. The human CS is tightly and bidirectionally interconnected to the stress system (SS). Both systems are fundamental for survival and regulate each other's activity in order to prepare the organism for the anticipated cyclic challenges. Thereby, the understanding of the temporal relationship between stressors and stress responses is critical for the comprehension of the molecular basis of physiology and pathogenesis of disease. A critical loss of the harmonious timed order at different organizational levels may affect the fundamental properties of neuroendocrine, immune, and autonomic systems, leading to a breakdown of biobehavioral adaptative mechanisms with increased stress sensitivity and vulnerability. In this review, following an overview of the functional components of the SS and CS, we present their multilevel interactions and discuss how traumatic stress can alter the interplay between the two systems. Circadian dysregulation after traumatic stress exposure may represent a core feature of trauma-related disorders mediating enduring neurobiological correlates of trauma through maladaptive stress regulation. Understanding the mechanisms susceptible to circadian dysregulation and their role in stress-related disorders could provide new insights into disease mechanisms, advancing psychochronobiological treatment possibilities and preventive strategies in stress-exposed populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.