Evidence map›Paper›PMID 32047440›Full record

ArticleFrontiers in pharmacology2019

Phenprocoumon Dose Requirements, Dose Stability and Time in Therapeutic Range in Elderly Patients With

Katharina Luise Schneider, Melanie Kunst, Ann-Kristin Leuchs, Miriam Böhme, Klaus Weckbecker, Kathrin Kastenmüller, Markus Bleckwenn, Stefan Holdenrieder, Christoph Coch, Gunther Hartmann and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Katharina Luise SchneiderResearch Division, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
Melanie KunstResearch Division, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
Ann-Kristin LeuchsResearch Division, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
Miriam BöhmeResearch Division, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
Klaus WeckbeckerInstitute of General Practice, Medical Faculty of the University of Düsseldorf, Düsseldorf, Germany.
Kathrin KastenmüllerInstitute of General Practice and Family Medicine, Medical Faculty of the University of Bonn, Bonn, Germany.
Markus BleckwennInstitute of General Practice and Family Medicine, Medical Faculty of the University of Bonn, Bonn, Germany.
Stefan HoldenriederInstitute of Laboratory Medicine, German Heart Centre Munich, Munich, Germany.
Christoph CochInstitute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty of the University of Bonn, Bonn, Germany.
Gunther HartmannInstitute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty of the University of Bonn, Bonn, Germany.
Julia Carolin StinglResearch Division, Federal Institute for Drugs and Medical Devices, Bonn, Germany.
University of Bonn · DEFederal Institute for Drugs and Medical Devices · DEDeutsches Herzzentrum München · DEHeinrich Heine University Düsseldorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDose requirements of vitamin K antagonists are associated with

methodsAim was to scrutinize phenprocoumon dose requirements, dose stability and anticoagulation quality in association to

resultsAverage weekly dose per patient was 14.4 ± 5.3 mg, 11.9 ± 4.0 mg and 11.2 ± 4.3 mg in DISCUSSION: Our analyses support the results of previous investigations regarding genotype-associated dose requirements and raise the hypothesis that dose stability and anticoagulation quality may be increased in CLINICAL

trial registrationGerman Clinical Trials Register, identifier DRKS00006256.

Indexed as

CYP2C9doseinternational normalized ratiophenprocoumontime in therapeutic rangeVKORC1

Identifiers

PMID32047440
PMCPMC6997201
OpenAlexW3002742373

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.