Evidence map›Paper›PMID 32047430›Full record

ArticleFrontiers in pharmacology2019

Regulation of X-Ray Irradiation on the Activity and Expression Levels of CYP1A2 and CYP2E1 in Rats.

Xiang-Yang Li, Ning Qu, Xue-Jun Wang, Jian-Xin Yang, Yuan-Yao Xin, Jun-Bo Zhu, Xue Bai, Ya-Bin Duan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Xiang-Yang LiState Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China.
Ning QuDepartment of Anesthesiology, Qinghai Hospital of Traditional Chinese Medicine, Xining, China.
Xue-Jun WangDepartment of Anesthesiology, Red Cross Hospital of Qinghai, Xining, China.
Jian-Xin YangMedical College, Qinghai University, Xining, China.
Yuan-Yao XinCollege of Eco-Environmental Engineering, Qinghai University, Xining, China.
Jun-Bo ZhuMedical College, Qinghai University, Xining, China.
Xue BaiMedical College, Qinghai University, Xining, China.
Ya-Bin DuanMedical College, Qinghai University, Xining, China.
Qinghai University · CNQinghai Red Cross Hospital · CNQinghai Tibetan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to investigate the regulation of X-ray irradiation and its effect on the activity and protein and mRNA expression levels of CYP1A2 and CYP2E1 in rats. Rats were randomly divided into 0 Gy (control), 1 Gy (low-dose irradiation), and 5 Gy (high-dose irradiation) groups. CYP1A2 and CYP2E1 activity was evaluated from changes in pharmacokinetic parameters of caffeine and chlorzoxazone, respectively. The plasma concentrations of the probe drugs were determined by high-performance liquid chromatography (HPLC). Enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR) tests were used to analyze the protein and mRNA expression levels of CYP1A2 and CYP2E1, respectively. The AUC

Indexed as

activityCYP1A2CYP2E1expressionpharmacokineticsX-ray irradiation

Identifiers

PMID32047430
PMCPMC6997339
OpenAlexW3002299776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.