Evidence map›Paper›PMID 32047273›Full record

ReviewMucosal immunology2020

The role of innate lymphoid cells in response to microbes at mucosal surfaces.

Goo-Young Seo, Daniel A Giles, Mitchell Kronenberg

Open access · bronzeAbstract readReview
In one paragraph

Review in Mucosal immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 55 citations in OpenAlex.

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  16. Expression of IL-1β in transgenicFrontiers in immunology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Goo-Young Seo *Division of Developmental Immunology, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Daniel A Giles *Division of Developmental Immunology, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA.
Mitchell KronenbergDivision of Developmental Immunology, La Jolla Institute for Immunology, 9420 Athena Circle, La Jolla, CA, 92037, USA. mitch@lji.org.
La Jolla Institute for Immunology · US

Funding

Using polygenic scores to enhance both variant discovery, and understanding of functional consequences of genetic variation in IBD.P01DK046763 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI MCGOVERN, DERMOT PATRICK · 1992 to 2020
$31.1M
The role of LIGHT in Colitis PathogenesisR01AI061516 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2004 to 2015
$4.5M
HVEM: A TNF family receptor that influences mucosal immunity and the microbiomeU01AI125955 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7M
The role of GPR183 in Inflammatory Bowel Disease pathogenesisF32AI140581 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI GILES, DANIEL AARON · 2018 to 2019
$89k
NIAID NIH HHS F32 AI140581NIAID NIH HHS R01 AI061516NIAID NIH HHS U01 AI125955NIDDK NIH HHS P01 DK046763
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a lymphocyte population that is mostly resident at mucosal surfaces. They help to induce an appropriate immune response to the microbiome at homeostasis. In healthy people, the mucosal immune system works symbiotically with organisms that make up the microbiota. ILCs play a critical role in orchestrating this balance, as they can both influence and in turn be influenced by the microbiome. ILCs also are important regulators of the early response to infections by diverse types of pathogenic microbes at mucosal barriers. Their rapid responses initiate inflammatory programs, production of antimicrobial products and repair processes. This review will focus on the role of ILCs in response to the microbiota and to microbial infections of the lung and intestine.

Indexed as

Immunity, InnateAnimalsBiomarkersCytokinesHomeostasisHost-Parasite InteractionsHost-Pathogen InteractionsHumansLymphocyte SubsetsMicrobiotaMucous MembraneBiomarkersCytokines

Identifiers

PMID32047273
PMCPMC7186215
OpenAlexW3006356360

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.