Evidence map›Paper›PMID 32047224›Full record

ArticleScientific reports2020

Immune protection is dependent on the gut microbiome in a lethal mouse gammaherpesviral infection.

Jordan R Yaron, Sriram Ambadapadi, Liqiang Zhang, Ramani N Chavan, Scott A Tibbetts, Shahar Keinan, Arvind Varsani, Juan Maldonado, Simona Kraberger, Amanda M Tafoya and 8 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Jordan R Yaron *Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID http://orcid.org/0000-0002-4133-474X
Sriram Ambadapadi *Center for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID https://orcid.org/0000-0001-6542-4259
Liqiang ZhangCenter for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID https://orcid.org/0000-0002-8808-8996
Ramani N ChavanCenter for Fundamental and Applied Microbiomics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Scott A TibbettsDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Shahar KeinanCloud Pharmaceuticals, Research Triangle Park (RTP), North Carolina, USA.ORCID https://orcid.org/0000-0001-8703-901X
Arvind VarsaniCenter for Fundamental and Applied Microbiomics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID http://orcid.org/0000-0003-4111-2415
Juan MaldonadoCenter for Fundamental and Applied Microbiomics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.ORCID http://orcid.org/0000-0002-2322-9620
Simona KrabergerCenter for Immunotherapy, Vaccines and Virotherapy, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Amanda M TafoyaCenter for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Whitney L BullardDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Jacquelyn KilbourneCenter for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Alison Stern-HarbutteDepartment of Molecular Genetics & Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
Rosa Krajmalnik-BrownCenter for Fundamental and Applied Microbiomics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Barbara H MunkCenter for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Erling O KoppangDepartment of Basic Sciences and Aquatic Medicine, Faculty of Veterinary Medicine, Norwegian University of Life Sciences, Oslo, Norway.
Efrem S LimCenter for Fundamental and Applied Microbiomics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA. efrem.lim@asu.edu.ORCID http://orcid.org/0000-0002-3397-9310
Alexandra R LucasCenter for Personalized Diagnostics, The Biodesign Institute, Arizona State University, Tempe, Arizona, USA. arlucas5@asu.edu.
Arizona State University · USUniversity of Florida · USCloud Pharmaceuticals (United States) · USNorwegian University of Life Sciences · NOUniversity of Cape Town · ZA

Funding

Manipulation of inflammasomes and NF-kB signaling in human myeloid cells by MyxomR01AI100987 · NIAID · UNIVERSITY OF FLORIDA · PI MCFADDEN, GRANT · 2013 to 2017
$1.9M
Serpin Modulation of Inflammatory Vasculitis; Potential for Immunomodulatory TherRC1HL100202 · NHLBI · UNIVERSITY OF FLORIDA · PI LUCAS, ALEXANDRA ROSE · 2009 to 2010
$1.0M
NHLBI NIH HHS RC1 HL100202NIAID NIH HHS R01 AI100987
6 · The paper itself

Abstract

Immunopathogenesis in systemic viral infections can induce a septic state with leaky capillary syndrome, disseminated coagulopathy, and high mortality with limited treatment options. Murine gammaherpesvirus-68 (MHV-68) intraperitoneal infection is a gammaherpesvirus model for producing severe vasculitis, colitis and lethal hemorrhagic pneumonia in interferon gamma receptor-deficient (IFNγR

Indexed as

Gastrointestinal MicrobiomeAnimalsAnti-Bacterial AgentsHerpesviridae InfectionsLungLymphocytesMicePeptide FragmentsRecombinant ProteinsSerpinsAnti-Bacterial AgentsPeptide FragmentsRecombinant ProteinsSerpins

Identifiers

PMID32047224
PMCPMC7012916
OpenAlexW3006603340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.