ReviewPediatrics2020
The Effects of Nicotine on Development.
Review in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
88 citing papers in PubMed, 4 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Nicotine Exposure During Pregnancy and Postnatal Cognitive Outcomes: A Systematic Review and Meta-Analysis.Acta paediatrica (Oslo, Norway : 1992) · 2026Pooled it
- Prenatal and postnatal factors associated with sudden infant death syndrome: an umbrella review of meta-analyses.World journal of pediatrics : WJP · 2024Pooled it
- A meta-analysis of the effects of vitamin C supplementation for pregnant smokers on the pulmonary function of their offspring.BMC pregnancy and childbirth · 2024Pooled it
- Determinants of rapid infant weight gain: A pooled analysis of seven cohorts.Pediatric obesity · 2022Pooled it
- Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Co-exposure to cannabinoids and nicotine increases senescence in prenatal human lung development.Pediatric research · 2026Article
- Prenatal cannabinoid and nicotine exposure: senescence as a developmental origin of bronchopulmonary dysplasia?Pediatric research · 2026Article
- Impact of a brief peri-operative counselling session on parental awareness of passive smoking in paediatric ambulatory surgery: A single-centre observational study.European journal of anaesthesiology and intensive care · 2026Article
- Emerging use of oral nicotine pouches among Canadian adolescents: Findings from the COMPASS-Quebec study.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Opposition to Youth e-Cigarette Prevention Campaigns on Twitter and TikTok: Cross-Platform Observational Mixed Methods Analysis.Journal of medical Internet research · 2026Observational
- Oral Nicotine Product Use and E-Cigarette Use Persistence in Adolescents and Young Adults: An Analysis Using Augmented Inverse Probability Weighting.American journal of epidemiology · 2026Article
- Do We Have Any Environmental or Perinatal Factor Which May Predispose for Paediatric Airways Diseases? An Italian Population Prospective Study.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- Governing E-cigarettes in China: regulatory challenges and strategies for adolescent protection in the post-flavor ban era.Frontiers in public health · 2026Article
- A qualitative study of same session co-use of nicotine and cannabis among adolescents and young adults.PloS one · 2026Article
- US drug policy does not align with experts' rankings of drug harms: a multi-criteria decision analysis.Harm reduction journal · 2025Article
- Thirdhand Smoke and Neonatal/Pediatric Health: A Scoping Review on Nursing Implications.Healthcare (Basel, Switzerland) · 2025Review
- Effects of selected alkaloids on postnatal neurogenesis - in vivo and in vitro studies - literature review.Psychopharmacology · 2025Review
- Tobacco and cannabis use among pregnant women with prenatal opioid use.Addictive behaviors · 2025Article
- Nicotine promotes the progression and metastasis of non-small cell lung cancer by modulating the OTUB1-c-Myc-EZH2 axis.Acta pharmacologica Sinica · 2025Article
- Single-cell profiling of H3K4me1-H3K27me3 revealed bivalent regulation of abnormal neuronal development caused by prenatal e-cigarette vaporing.Communications biology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Recently, there has been a significant increase in the use of noncombustible nicotine-containing products, including electronic cigarettes (e-cigarettes). Of increasing popularity are e-cigarettes that can deliver high doses of nicotine over short periods of time. These devices have led to a rise in nicotine addiction in adolescent users who were nonsmokers. Use of noncombustible nicotine products by pregnant mothers is also increasing and can expose the developing fetus to nicotine, a known teratogen. In addition, young children are frequently exposed to secondhand and thirdhand nicotine aerosols generated by e-cigarettes, with little understanding of the effects these exposures can have on health. With the advent of these new nicotine-delivery systems, many concerns have arisen regarding the short- and long-term health effects of nicotine on childhood health during all stages of development. Although health studies on nicotine exposure alone are limited, educating policy makers and health care providers on the potential health effects of noncombustible nicotine is needed because public acceptance of these products has become so widespread. Most studies evaluating the effects of nicotine on health have been undertaken in the context of smoke exposure. Nevertheless, in vitro and in vivo preclinical studies strongly indicate that nicotine exposure alone can adversely affect the nervous, respiratory, immune, and cardiovascular systems, particularly when exposure occurs during critical developmental periods. In this review, we have included both preclinical and clinical studies to identify age-related health effects of nicotine exposure alone, examining the mechanisms underlying these effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.