Evidence map›Paper›PMID 32047095›Full record

ArticleGenetics2020

Genetic Contributions to Maternal and Neonatal Vitamin D Levels.

Michela Traglia, Gayle C Windham, Michelle Pearl, Victor Poon, Darryl Eyles, Karen L Jones, Kristen Lyall, Martin Kharrazi, Lisa A Croen, Lauren A Weiss

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Steroid hormone pathways, vitamin D and autism: a systematic review.Journal of neural transmission (Vienna, Austria : 1996) · 2023
    Pooled it
  2. Pooled it
  3. Article
  4. Journal of clinical practice and research · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Observational
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 2 countries.

Michela TragliaDepartment of Psychiatry, Institute for Human Genetics, University of California, San Francisco, California 94143.
Gayle C WindhamCalifornia Department of Public Health, Environmental Health Investigations Branch, Richmond, California 94804.
Michelle PearlCalifornia Department of Public Health, Environmental Health Investigations Branch, Richmond, California 94804.
Victor PoonSequoia Foundation, La Jolla, California 92037.
Darryl EylesQueensland Brain Institute, University of Queensland, Brisbane, 4072, Australia.
Karen L JonesDivision of Rheumatology, Allergy and Clinical Immunology, University of California, Davis, California 95616.
Kristen LyallA.J. Drexel Autism Institute, Drexel University, Philadelphia, Pennsylvania 191044.
Martin KharraziCalifornia Department of Public Health, Environmental Health Investigations Branch, Richmond, California 94804.
Lisa A CroenAutism Research Program, Division of Research, Kaiser Permanente, Oakland, California 94612.
Lauren A WeissDepartment of Psychiatry, Institute for Human Genetics, University of California, San Francisco, California 94143.ORCID 0000-0002-5700-135X
California Department of Public Health · USUniversity of California, San Francisco · USDrexel University · USKaiser Permanente · USSequoia Foundation · USThe University of Queensland · AUUniversity of California, Davis · US

Funding

Prenatal and Neonatal Biologic Markers for AutismR01ES016669 · NIEHS · KAISER FOUNDATION RESEARCH INSTITUTE · PI CROEN, LISA A · 2010 to 2014
$3.5M
Role of pre-natal Vitamin D and gene interactions in Autism Spectrum Disorders; leveraging an existing case-control studyR01HD079533 · NICHD · SEQUOIA FOUNDATION · PI WINDHAM, GAYLE · 2015 to 2017
$795k
NICHD NIH HHS R01 HD079533NIEHS NIH HHS R01 ES016669
6 · The paper itself

Abstract

Vitamin D is essential for several physiological functions and biological processes. Increasing levels of maternal vitamin D are required throughout pregnancy as a unique source of vitamin D for the fetus, and consequently maternal vitamin D deficiency may result in several adverse outcomes in newborns. However, the genetic regulation of vitamin D in pregnancy and at birth is not yet well understood. We performed genome-wide association studies of maternal midgestational serum-derived and neonatal blood-spot-derived total 25-hydroxyvitamin D from a case-control study of autism spectrum disorder (ASD). We identified one fetal locus (rs4588) significantly associated with neonatal vitamin D levels in the

Indexed as

Polymorphism, Single NucleotideAdultAutism Spectrum DisorderChemokine CXCL6Duffy Blood-Group SystemFemaleFetal BloodHumansInfant, NewbornInterleukin-8PregnancyProtein Kinase CReceptors, Cell SurfaceVitamin DVitamin D-Binding ProteinACKR1 protein, humanChemokine CXCL6CXCL6 protein, humanDuffy Blood-Group SystemGC protein, humanInterleukin-8Protein Kinase Cprotein kinase NReceptors, Cell SurfaceVitamin DVitamin D-Binding Proteinautismearly developmentGC pregnancyGWASimmune functionintellectual disabilitymaternal and fetal geneticsneonatesSNP-based heritabilityvitamin D

Identifiers

PMID32047095
PMCPMC7153928
OpenAlexW3005630818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.