ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Synaptic Plasticity Depends on the Fine-Scale Input Pattern in Thin Dendrites of CA1 Pyramidal Neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- Deep learning-assisted mapping of dendritic spines using sequential 2D two-photon calcium imaging.iScience · 2026Article
- Distinct types of dendritic CaScience advances · 2026Article
- Altered Structural Plasticity Mediated by mGlu and NMDA Receptors and Impaired Cognition in a Genetic ASD Model (Shank3The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Diverse calcium dynamics underlie place field formation in hippocampal CA1 pyramidal cells.eLife · 2025Article
- Increased excitatory synapse size in hippocampal place cells compared to silent cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Distinct synaptic plasticity rules operate across dendritic compartments in vivo during learning.Science (New York, N.Y.) · 2025Article
- Synaptic plasticity rules driving representational shifting in the hippocampus.Nature neuroscience · 2025Article
- ClScience advances · 2024Article
- A dendritic mechanism for balancing synaptic flexibility and stability.Cell reports · 2024Article
- A voltage-based Event-Timing-Dependent Plasticity rule accounts for LTP subthreshold and suprathreshold for dendritic spikes in CA1 pyramidal neurons.Journal of computational neuroscience · 2024Article
- Heterosynaptic plasticity-induced modulation of synapses.The journal of physiological sciences : JPS · 2023Review
- Making time and space for calcium control of neuron activity.Current opinion in neurobiology · 2023Review
- Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules.Molecular and cellular neurosciences · 2023Review
- Synaptic Plasticity Is Predicted by Spatiotemporal Firing Rate Patterns and Robust to In Vivo-like Variability.Biomolecules · 2022Article
- Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration.Annual review of neuroscience · 2021Article
- Emergence of local and global synaptic organization on cortical dendrites.Nature communications · 2021Article
- The functional organization of excitatory synaptic input to place cells.Nature communications · 2021Article
- Heterosynaptic Plasticity and the Experience-Dependent Refinement of Developing Neuronal Circuits.Frontiers in neural circuits · 2021Review
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Coordinated long-term plasticity of nearby excitatory synaptic inputs has been proposed to shape experience-related neuronal information processing. To elucidate the induction rules leading to spatially structured forms of synaptic potentiation in dendrites, we explored plasticity of glutamate uncaging-evoked excitatory input patterns with various spatial distributions in perisomatic dendrites of CA1 pyramidal neurons in slices from adult male rats. We show that (1) the cooperativity rules governing the induction of synaptic LTP depend on dendritic location; (2) LTP of input patterns that are subthreshold or suprathreshold to evoke local dendritic spikes (d-spikes) requires different spatial organization; and (3) input patterns evoking d-spikes can strengthen nearby, nonsynchronous synapses by local heterosynaptic plasticity crosstalk mediated by NMDAR-dependent MEK/ERK signaling. These results suggest that multiple mechanisms can trigger spatially organized synaptic plasticity on various spatial and temporal scales, enriching the ability of neurons to use synaptic clustering for information processing.
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Registered trials
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