ArticleBMJ open2020
Lipid accumulation product and late-onset hypogonadism in middle-aged and elderly men: results from a cross-sectional study in China.
Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Association between estimated glucose disposal rate and testosterone deficiency in male patients with type 2 diabetes mellitus.BMC endocrine disorders · 2025Article
- Association between estimated glucose disposal rate and testosterone level in US adult men: insights from NHANES 2013-2016.Sexual medicine · 2025Article
- Negative correlation between metabolic score for insulin resistance index and testosterone in male adults.Diabetology & metabolic syndrome · 2024Article
- Investigating a novel surrogate indicator of adipose accumulation in relation to erectile dysfunction.Lipids in health and disease · 2024Article
- Cardiometabolic indices predict hypogonadism in male patients with type 2 diabetes.Journal of endocrinological investigation · 2023Article
- A negative association between triglyceride glucose-body mass index and testosterone in adult males: a cross-sectional study.Frontiers in endocrinology · 2023Article
- Association between hypertriglyceridemic waist phenotype and hypogonadism in Taiwanese adult men.PloS one · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
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Abstract
objectivesHypogonadism in men is related to the deterioration of general health. However, the association between lipid overaccumulation and ageing-related hypogonadism remains an undetermined concept. We aimed to provide an insight into the possible links between the lipid accumulation product (LAP) and late-onset hypogonadism (LOH).
settingSun Yat-sen Memorial Hospital of Sun Yat-sen University.
participantsWe included a population sample of 997 subjects aged 40 years or older. PRIMARY AND SECONDARY OUTCOME MEASURES: The LAP was calculated by gender-specific equations using waist circumference (WC) and triglyceride (TG). LOH was defined by the presence of androgen deficiency symptoms and low serum total testosterone levels.
resultsThe prevalence of LOH was 9.4% in this population and gradually increased according to increasing LAP quartiles. Compared with subjects without LOH, ageing men with LOH had higher body mass index, WC, systolic blood pressure, percentage of subjects currently smoking, TG and follicle stimulating hormone and lower low-density lipoprotein cholesterol and sex hormone binding globulin. In multivariate logistic regression analysis, the adjusted ORs of LOH for increasing LAP quartiles 1-4 were 1.00 (reference), 1.10 (95% CI 0.45-2.69), 2.15 (95% CI 0.93-4.94) and 3.83 (95% CI 1.73-8.45), respectively.
conclusionBody lipid accumulation evaluated by the LAP is independently associated with the prevalence of LOH in middle-aged and elderly Chinese men.
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