Observational studyBMJ open2020
Impact of sex and myocardial function on association of obesity with mortality in Asian patients with acute heart failure: a retrospective analysis from the STRATS-AHF registry.
Observational study in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03513653 (Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure), which is not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strain for Risk Assessment and Therapeutic Strategies in Patients With Acute Heart Failure (STRATS-AHF) Registry
Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
- Obesity paradox in heart failure with and without diabetes mellitus: a retrospective cohort study : Obesity paradox and DM in HF.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Relation of glucose variability on mortality from any cause and cardiovascular diseases in individuals with type 2 diabetes: mediation analysis of echocardiographic parameters.BMC cardiovascular disorders · 2025Article
- The intersection of obesity and acute heart failure: cardiac structure and function and congestion across BMI categories.European heart journal. Acute cardiovascular care · 2025Article
- Characteristics, Predictors, and Clinical Outcomes in Heart Failure With Reduced Ejection Fraction According to a 1-Year Left Ventricular Ejection Fraction Following Sacubitril/Valsartan Treatment.Journal of the American Heart Association · 2024Observational
- Obesity: the perfect storm for heart failure.ESC heart failure · 2024Review
- Is the obesity paradox in outpatients with heart failure reduced ejection fraction real?Frontiers in cardiovascular medicine · 2023Article
- Abdominal Obesity Is Associated with an Increased Risk of All-Cause Mortality in Males but Not in Females with HFpEF.Cardiovascular therapeutics · 2022Article
- The Relationship Between Body Mass Index and In-hospital Survival in Patients Admitted With Acute Heart Failure.Frontiers in cardiovascular medicine · 2022Article
- Effect of obesity on cardiovascular responses to submaximal treadmill exercise in adult males.Journal of family medicine and primary care · 2020Article
- Waist circumference is associated with major adverse cardiovascular events in male but not female patients with type-2 diabetes mellitus.Cardiovascular diabetology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesImpact of sex and myocardial function on the obesity paradox in heart failure (HF) is unknown. We explored whether sex, myocardial function, and left ventricular (LV) geometry explains the protective association of body mass index (BMI) with mortality, and investigated whether metabolic health status affects this association.
designA multicentre cohort study with patients with acute HF admitted from January 2009 to December 2016 with a median follow-up of 33.7 months.
settingThree tertiary hospitals.
participantsA total of 2021 overweight-to-obese (OW) and 1543 normal-weight (NW) patients with acute HF. MEASUREMENTS: The primary outcome was all-cause mortality. Patients were categorised as either OW (BMI≥23kg/m
resultsDuring the follow-up period, 1392 patients died (685 OW and 707 NW). BMI was significantly associated with mortality in univariate (HR=0.929 per kg/m
conclusionsIn women, a significant interaction was observed between BMI and age or LV-GLS in association with mortality, suggesting that sex, ageing and myocardial dysfunction can affect the magnitude of the obesity paradox in HF. Metabolic health status provides prognostic information beyond obesity status. TRIAL REGISTRATION NUMBER: Registry: ClinicalTrials.gov Number: NCT03513653 (https://clinicaltrials.gov/ct2/show/NCT03513653).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.