ArticleBMC complementary medicine and therapies2020
In vitro Cariostatic effects of cinnamon water extract on nicotine-induced Streptococcus mutans biofilm.
Article in BMC complementary medicine and therapies, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Evaluation of the antimicrobial potential of fluoride-free mouthwashes against Scardovia wiggsiae.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026Article
- Bacteriophage-mediated biofilm control: a novel targeted strategy for the management of dental caries.Frontiers in cellular and infection microbiology · 2026Review
- A Review of the Impact of Green Tea (Current pharmaceutical design · 2026Review
- Investigation of Antimicrobial Potential of Medicinal Plants AgainstFood science & nutrition · 2025Article
- Evaluating the efficacy of Chenopodium murale plant extract in inhibiting Streptococcus mutans and reducing dental caries risk.Scientific reports · 2025Article
- In Silico Docking of Medicinal Herbs Against P. gingivalis for Chronic Periodontitis Intervention.International dental journal · 2025Article
- Exploration of the primary antibiofilm substance and mechanism employed byFrontiers in cellular and infection microbiology · 2025Article
- Cariostatic Agents: From Silver Diamine Fluoride to Emerging Bioactive Compounds.Clinical, cosmetic and investigational dentistry · 2025Review
- Inhibition of the Biofilm Formation of PlantPharmaceuticals (Basel, Switzerland) · 2024Review
- Tobacco-enhanced biofilm formation by Porphyromonas gingivalis and other oral microbes.Molecular oral microbiology · 2024Review
- Plant-Derived Compounds: A Promising Tool for Dental Caries Prevention.Current issues in molecular biology · 2024Review
- Six Spain Thymus essential oils composition analysis and their in vitro and in silico study against Streptococcus mutans.BMC complementary medicine and therapies · 2023Article
- Postbiotics Derived fromMolecules (Basel, Switzerland) · 2023Article
- Article
- Novel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials.Clinical oral investigations · 2022Article
- The application of selenium nanoparticles for enhancing the efficacy of photodynamic inactivation of planktonic communities and the biofilm of Streptococcus mutans.BMC research notes · 2022Article
- Review
- Effects of Cinnamon (Molecules (Basel, Switzerland) · 2020Review
- Microbial Etiology and Prevention of Dental Caries: Exploiting Natural Products to Inhibit Cariogenic Biofilms.Pathogens (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDental caries is one of the most prevalent chronic oral diseases worldwide. Dental caries is mainly associated with Streptococcus mutans and the Lactobacillus species. A specific relationship was found between nicotine and S. mutans growth as the presence of nicotine increased S. mutans biofilm formation. Nicotine is able to increase the number of S. mutans and extracellular polysaccharide (EPS) synthesis. Among the widely used herbs and spices is cinnamon which demonstrated a strong antibacterial activity against a wide variety of bacteria including S. mutans and showed the ability to inhibit S. mutans biofilm formation. Cinnamon essential oil, obtained from the leaves of C. zeylanicum, has been demonstrated to be effective against S. mutans and Lactobacillus acidophilus, which are partially responsible for dental plaque formation and caries development. The aim of this study was to identify the effects of nicotine exposure on the inhibitory effects of cinnamon water extract on S. mutans biofilm formation. MATERIALS AND
methodsA 24-h culture of S. mutans UA159 in microtiter plates was treated with varying nicotine concentrations (0-32 mg/ml) in Tryptic Soy broth supplemented with 1% sucrose (TSBS) with or without a standardized concentration (2.5 mg/ml) of cinnamon water extract. A spectrophotometer was used to determine total growth absorbance and planktonic growth. The microtiter plate wells were washed, fixed and stained with crystal violet dye and the absorbance measured to determine biofilm formation.
resultsThe presence of 2.5 mg/ml cinnamon water extract inhibits nicotine-induced S. mutans biofilm formation from 34 to 98% at different concentrations of nicotine (0-32 mg/ml).
conclusionThe results demonstrated nicotine-induced S. mutans biofilm formation is decreased from 34 to 98% in the presence of 2.5 mg/ml cinnamon water extract. This provides further evidence about the biofilm inhibitory properties of cinnamon water extract and reconfirms the harmful effects of nicotine.
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