Observational studyBMC cardiovascular disorders2020
Body fat percentage and CRP correlates with a composite score of vascular risk markers in healthy, young adults - The Lifestyle, Biomarkers, and Atherosclerosis (LBA) study.
Observational study in BMC cardiovascular disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Leptin, CRP, and adiponectin correlate with body fat percentage in adolescents: systematic review and meta-analysis.Frontiers in nutrition · 2025Pooled it
- When the sum isn't the whole - The vascular status score and its components in hypertension identification: The African PREDICT study.Journal of human hypertension · 2026Article
- The association between body composition and arterial stiffness: investigating the influence of inflammatory markers.Frontiers in cardiovascular medicine · 2026Article
- Association Between High-Sensitivity C-Reactive Protein and Longitudinal Changes in Arteriosclerosis Over Time: The Kailuan Prospective Cohort Study.Journal of inflammation research · 2025Article
- Influence of cardiorespiratory fitness and body composition on resting and post-exercise indices of vascular health in young adults.Sports medicine and health science · 2024Article
- Association between C10X polymorphism in the CARD8 gene and inflammatory markers in young healthy individuals in the LBA study.BMC cardiovascular disorders · 2024Article
- Higher pulse wave velocity in young adult offspring of mothers with type 1 diabetes: a case-control study.Cardiovascular diabetology · 2022Article
- Association of ideal cardiovascular health with carotid intima-media thickness (cIMT) in a young adult population.Scientific reports · 2022Article
- CRP levels are significantly associated with CRP genotype and estrogen use in The Lifestyle, Biomarker and Atherosclerosis (LBA) study.BMC cardiovascular disorders · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIdentification of early signs of atherosclerosis in young adults have the potential to guide early interventions to prevent later cardiovascular disease. We therefore analyzed measures of vascular structure and function and biomarkers of cardiovascular risk in a sample of young healthy adults.
methodsPulse-wave velocity (PWV), carotid-intima media thickness (cIMT) and augmentation index (AIX) were measured in 834 healthy non-smokers (ages 18.0-25.9). Emphasis was put on discriminating between individuals having a vascular structure and function associated with a higher or lower risk, and cluster analysis algorithms were employed to assign the subjects into groups based on these vascular measurements. In addition, a vascular status score (VSS) was calculated by summarizing the results according to quintiles of the vascular measurements. The associations between VSS and cardiovascular biomarkers were examined by regression analyses.
resultsThe cluster analyses did not yield sufficiently distinct clustering (groups of individuals that could be categorized unequivocally as having either a vascular structure and function associated with a higher or lower CVD risk). VSS proved a better classificatory variable. The associations between VSS and biomarkers of cardiovascular risk were analyzed by univariable and multivariable regressions. Only body fat percentage and C-reactive protein (CRP) were independently associated with VSS.
conclusionsA VSS calculation, which integrates PWV, cIMT, and AIX measurements is better suited for cardiovascular risk evaluation in young adults than cluster analyses. The independent associations of VSS with body fat percentage and CRP highlight the decisive role of adiposity and systemic inflammation in early atherosclerotic progression and suggests a subordinate role of insulin and lipid metabolism in this age span.
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